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Anti-DHCR7 monoclonal antibody
Pre-made anti-DHCR7 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DHCR7/DHCR7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0689-Ab-1/ GM-Tg-hg-IP0689-Ab-2 | Anti-Human DHCR7 monoclonal antibody | Human |
| GM-Tg-rg-IP0689-Ab-1/ GM-Tg-rg-IP0689-Ab-2 | Anti-Rat DHCR7 monoclonal antibody | Rat |
| GM-Tg-mg-IP0689-Ab-1/ GM-Tg-mg-IP0689-Ab-2 | Anti-Mouse DHCR7 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0689-Ab-1/ GM-Tg-cynog-IP0689-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DHCR7 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0689-Ab-1/ GM-Tg-felg-IP0689-Ab-2 | Anti-Feline DHCR7 monoclonal antibody | Feline |
| GM-Tg-cang-IP0689-Ab-1/ GM-Tg-cang-IP0689-Ab-2 | Anti-Canine DHCR7 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0689-Ab-1/ GM-Tg-bovg-IP0689-Ab-2 | Anti-Bovine DHCR7 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0689-Ab-1/ GM-Tg-equg-IP0689-Ab-2 | Anti-Equine DHCR7 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0689-Ab-1/ GM-Tg-hg-IP0689-Ab-2; GM-Tg-rg-IP0689-Ab-1/ GM-Tg-rg-IP0689-Ab-2; GM-Tg-mg-IP0689-Ab-1/ GM-Tg-mg-IP0689-Ab-2; GM-Tg-cynog-IP0689-Ab-1/ GM-Tg-cynog-IP0689-Ab-2; GM-Tg-felg-IP0689-Ab-1/ GM-Tg-felg-IP0689-Ab-2; GM-Tg-cang-IP0689-Ab-1/ GM-Tg-cang-IP0689-Ab-2; GM-Tg-bovg-IP0689-Ab-1/ GM-Tg-bovg-IP0689-Ab-2; GM-Tg-equg-IP0689-Ab-1/ GM-Tg-equg-IP0689-Ab-2 |
| Products Name | Anti-DHCR7 monoclonal antibody |
| Format | mab |
| Target Name | DHCR7 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DHCR7 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0689-Ag-1 | Recombinant multi-species DHCR7/ SLOS protein |
| ORF Viral Vector | pGMLP003746 | human DHCR7 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003746 | human DHCR7 Lentivirus particle |
| ORF Viral Vector | pGMLPm001833 | mouse Dhcr7 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001833 | mouse Dhcr7 Lentivirus particle |
Target information
| Target ID | GM-IP0689 |
| Target Name | DHCR7 |
| Gene ID | 1717,13360,64191,106993167,483675,101089143,514745,100061433 |
| Gene Symbol and Synonyms | DHCR7,SLOS |
| Uniprot Accession | Q9UBM7,Q9Z2Z8,Q5E9J5 |
| Uniprot Entry Name | DHCR7_HUMAN,DHCR7_RAT,DHCR7_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000172893 |
| Target Classification | N/A |
The target: DHCR7, gene name: DHCR7, also named as SLOS. This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Aug 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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