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Anti-DMTF1 monoclonal antibody
Pre-made anti-DMTF1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DMTF1/DMTF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0699-Ab-1/ GM-Tg-hg-IP0699-Ab-2 | Anti-Human DMTF1 monoclonal antibody | Human |
| GM-Tg-rg-IP0699-Ab-1/ GM-Tg-rg-IP0699-Ab-2 | Anti-Rat DMTF1 monoclonal antibody | Rat |
| GM-Tg-mg-IP0699-Ab-1/ GM-Tg-mg-IP0699-Ab-2 | Anti-Mouse DMTF1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0699-Ab-1/ GM-Tg-cynog-IP0699-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DMTF1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0699-Ab-1/ GM-Tg-felg-IP0699-Ab-2 | Anti-Feline DMTF1 monoclonal antibody | Feline |
| GM-Tg-cang-IP0699-Ab-1/ GM-Tg-cang-IP0699-Ab-2 | Anti-Canine DMTF1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0699-Ab-1/ GM-Tg-bovg-IP0699-Ab-2 | Anti-Bovine DMTF1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0699-Ab-1/ GM-Tg-equg-IP0699-Ab-2 | Anti-Equine DMTF1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0699-Ab-1/ GM-Tg-hg-IP0699-Ab-2; GM-Tg-rg-IP0699-Ab-1/ GM-Tg-rg-IP0699-Ab-2; GM-Tg-mg-IP0699-Ab-1/ GM-Tg-mg-IP0699-Ab-2; GM-Tg-cynog-IP0699-Ab-1/ GM-Tg-cynog-IP0699-Ab-2; GM-Tg-felg-IP0699-Ab-1/ GM-Tg-felg-IP0699-Ab-2; GM-Tg-cang-IP0699-Ab-1/ GM-Tg-cang-IP0699-Ab-2; GM-Tg-bovg-IP0699-Ab-1/ GM-Tg-bovg-IP0699-Ab-2; GM-Tg-equg-IP0699-Ab-1/ GM-Tg-equg-IP0699-Ab-2 |
| Products Name | Anti-DMTF1 monoclonal antibody |
| Format | mab |
| Target Name | DMTF1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DMTF1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0699-Ag-1 | Recombinant multi-species DMTF1/ DMP1/ DMTF protein |
| ORF Viral Vector | pGMLPm005185 | mouse Dmtf1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005185 | mouse Dmtf1 Lentivirus particle |
Target information
| Target ID | GM-IP0699 |
| Target Name | DMTF1 |
| Gene ID | 9988,23857,114485,706292,475217,101096302,539676,100049982 |
| Gene Symbol and Synonyms | Dimp,DMP1,DMTF,DMTF1,hDMP1,MRUL |
| Uniprot Accession | Q9Y222,Q66HG1 |
| Uniprot Entry Name | DMTF1_HUMAN,DMTF1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000135164 |
| Target Classification | N/A |
The target: DMTF1, gene name: DMTF1, also named as DMP1, DMTF, MRUL, hDMP1. This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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