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Anti-DMXL2 monoclonal antibody
Pre-made anti-DMXL2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DMXL2/DMXL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0700-Ab-1/ GM-Tg-hg-IP0700-Ab-2 | Anti-Human DMXL2 monoclonal antibody | Human |
| GM-Tg-rg-IP0700-Ab-1/ GM-Tg-rg-IP0700-Ab-2 | Anti-Rat DMXL2 monoclonal antibody | Rat |
| GM-Tg-mg-IP0700-Ab-1/ GM-Tg-mg-IP0700-Ab-2 | Anti-Mouse DMXL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0700-Ab-1/ GM-Tg-cynog-IP0700-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DMXL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0700-Ab-1/ GM-Tg-felg-IP0700-Ab-2 | Anti-Feline DMXL2 monoclonal antibody | Feline |
| GM-Tg-cang-IP0700-Ab-1/ GM-Tg-cang-IP0700-Ab-2 | Anti-Canine DMXL2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0700-Ab-1/ GM-Tg-bovg-IP0700-Ab-2 | Anti-Bovine DMXL2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0700-Ab-1/ GM-Tg-equg-IP0700-Ab-2 | Anti-Equine DMXL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0700-Ab-1/ GM-Tg-hg-IP0700-Ab-2; GM-Tg-rg-IP0700-Ab-1/ GM-Tg-rg-IP0700-Ab-2; GM-Tg-mg-IP0700-Ab-1/ GM-Tg-mg-IP0700-Ab-2; GM-Tg-cynog-IP0700-Ab-1/ GM-Tg-cynog-IP0700-Ab-2; GM-Tg-felg-IP0700-Ab-1/ GM-Tg-felg-IP0700-Ab-2; GM-Tg-cang-IP0700-Ab-1/ GM-Tg-cang-IP0700-Ab-2; GM-Tg-bovg-IP0700-Ab-1/ GM-Tg-bovg-IP0700-Ab-2; GM-Tg-equg-IP0700-Ab-1/ GM-Tg-equg-IP0700-Ab-2 |
| Products Name | Anti-DMXL2 monoclonal antibody |
| Format | mab |
| Target Name | DMXL2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DMXL2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0700-Ag-1 | Recombinant multi-species DMXL2/ DFNA71/ PEPNS protein |
Target information
| Target ID | GM-IP0700 |
| Target Name | DMXL2 |
| Gene ID | 23312,235380,315676,693954,478306,101082573,782535,100055186 |
| Gene Symbol and Synonyms | 6330586A12,6430411K14Rik,DEE81,DFNA71,DMXL2,Dmxl2-ps1,E130119P06Rik,EIEE81,mKIAA0856,PEPNS,RC3 |
| Uniprot Accession | Q8TDJ6 |
| Uniprot Entry Name | DMXL2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000104093 |
| Target Classification | N/A |
The target: DMXL2, gene name: DMXL2, also named as DFNA71, PEPNS, RC3. This gene encodes a protein with 12 WD domains. Proteins with WD domains are involved in many functions including participation in signal transduction pathways. Participation of the encoded protein in regulation of the Notch signaling pathway has been demonstrated in vitro using several human cell lines (PMID:20810660). A gene encoding a similar protein is located on chromosome 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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