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Anti-DOLK monoclonal antibody
Pre-made anti-DOLK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to DOLK/DOLK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0717-Ab-1/ GM-Tg-hg-IP0717-Ab-2 | Anti-Human DOLK monoclonal antibody | Human |
| GM-Tg-rg-IP0717-Ab-1/ GM-Tg-rg-IP0717-Ab-2 | Anti-Rat DOLK monoclonal antibody | Rat |
| GM-Tg-mg-IP0717-Ab-1/ GM-Tg-mg-IP0717-Ab-2 | Anti-Mouse DOLK monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0717-Ab-1/ GM-Tg-cynog-IP0717-Ab-2 | Anti-Cynomolgus/ Rhesus macaque DOLK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0717-Ab-1/ GM-Tg-felg-IP0717-Ab-2 | Anti-Feline DOLK monoclonal antibody | Feline |
| GM-Tg-cang-IP0717-Ab-1/ GM-Tg-cang-IP0717-Ab-2 | Anti-Canine DOLK monoclonal antibody | Canine |
| GM-Tg-bovg-IP0717-Ab-1/ GM-Tg-bovg-IP0717-Ab-2 | Anti-Bovine DOLK monoclonal antibody | Bovine |
| GM-Tg-equg-IP0717-Ab-1/ GM-Tg-equg-IP0717-Ab-2 | Anti-Equine DOLK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0717-Ab-1/ GM-Tg-hg-IP0717-Ab-2; GM-Tg-rg-IP0717-Ab-1/ GM-Tg-rg-IP0717-Ab-2; GM-Tg-mg-IP0717-Ab-1/ GM-Tg-mg-IP0717-Ab-2; GM-Tg-cynog-IP0717-Ab-1/ GM-Tg-cynog-IP0717-Ab-2; GM-Tg-felg-IP0717-Ab-1/ GM-Tg-felg-IP0717-Ab-2; GM-Tg-cang-IP0717-Ab-1/ GM-Tg-cang-IP0717-Ab-2; GM-Tg-bovg-IP0717-Ab-1/ GM-Tg-bovg-IP0717-Ab-2; GM-Tg-equg-IP0717-Ab-1/ GM-Tg-equg-IP0717-Ab-2 |
| Products Name | Anti-DOLK monoclonal antibody |
| Format | mab |
| Target Name | DOLK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-DOLK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0717-Ag-1 | Recombinant multi-species DOLK/ CDG1M/ DK protein |
| ORF Viral Vector | vGMLP002086 | human DOLK Lentivirus particle |
| ORF Viral Vector | pGMLP002086 | human DOLK Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005208 | mouse Dolk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005208 | mouse Dolk Lentivirus particle |
Target information
| Target ID | GM-IP0717 |
| Target Name | DOLK |
| Gene ID | 22845,227697,311847,717045,480701,101083720,526844,100070129 |
| Gene Symbol and Synonyms | CDG1M,DK,DK1,DOLK,mKIAA1094,SEC59,™EM15 |
| Uniprot Accession | Q9UPQ8,Q58CR4 |
| Uniprot Entry Name | DOLK_HUMAN,DOLK_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000175283 |
| Target Classification | N/A |
The target: DOLK, gene name: DOLK, also named as CDG1M, DK, DK1, SEC59, ™EM15. The protein encoded by this gene catalyzes the CTP-mediated phosphorylation of dolichol, and is involved in the synthesis of Dol-P-Man, which is an essential glycosyl carrier lipid for C- and O-mannosylation, N- and O-linked glycosylation of proteins, and for the biosynthesis of glycosyl phosphatidylinositol anchors in endoplasmic reticulum. Mutations in this gene are associated with dolichol kinase deficiency.[provided by RefSeq, Apr 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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