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Anti-EPSTI1 monoclonal antibody
Pre-made anti-EPSTI1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to EPSTI1/EPSTI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0763-Ab-1/ GM-Tg-hg-IP0763-Ab-2 | Anti-Human EPSTI1 monoclonal antibody | Human |
| GM-Tg-rg-IP0763-Ab-1/ GM-Tg-rg-IP0763-Ab-2 | Anti-Rat EPSTI1 monoclonal antibody | Rat |
| GM-Tg-mg-IP0763-Ab-1/ GM-Tg-mg-IP0763-Ab-2 | Anti-Mouse EPSTI1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0763-Ab-1/ GM-Tg-cynog-IP0763-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPSTI1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0763-Ab-1/ GM-Tg-felg-IP0763-Ab-2 | Anti-Feline EPSTI1 monoclonal antibody | Feline |
| GM-Tg-cang-IP0763-Ab-1/ GM-Tg-cang-IP0763-Ab-2 | Anti-Canine EPSTI1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0763-Ab-1/ GM-Tg-bovg-IP0763-Ab-2 | Anti-Bovine EPSTI1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0763-Ab-1/ GM-Tg-equg-IP0763-Ab-2 | Anti-Equine EPSTI1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0763-Ab-1/ GM-Tg-hg-IP0763-Ab-2; GM-Tg-rg-IP0763-Ab-1/ GM-Tg-rg-IP0763-Ab-2; GM-Tg-mg-IP0763-Ab-1/ GM-Tg-mg-IP0763-Ab-2; GM-Tg-cynog-IP0763-Ab-1/ GM-Tg-cynog-IP0763-Ab-2; GM-Tg-felg-IP0763-Ab-1/ GM-Tg-felg-IP0763-Ab-2; GM-Tg-cang-IP0763-Ab-1/ GM-Tg-cang-IP0763-Ab-2; GM-Tg-bovg-IP0763-Ab-1/ GM-Tg-bovg-IP0763-Ab-2; GM-Tg-equg-IP0763-Ab-1/ GM-Tg-equg-IP0763-Ab-2 |
| Products Name | Anti-EPSTI1 monoclonal antibody |
| Format | mab |
| Target Name | EPSTI1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-EPSTI1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0763-Ag-1 | Recombinant multi-species ESIP1/ EPSTI1/ BRESI1 protein |
Target information
| Target ID | GM-IP0763 |
| Target Name | EPSTI1 |
| Gene ID | 94240,108670,498547,700208,476931,101089570,614555,100051337 |
| Gene Symbol and Synonyms | 2310046K10Rik,5033415K03Rik,BRESI1,EPSTI1,RGD1563207 |
| Uniprot Accession | Q96J88,Q5BK43 |
| Uniprot Entry Name | ESIP1_HUMAN,ESIP1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000133106 |
| Target Classification | N/A |
The target: EPSTI1, gene name: EPSTI1, also named as BRESI1. The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 protein to promoter sequences. The translated protein interacts with the amino terminal region of the valosin containing protein gene product, resulting in the nuclear translocation of the nuclear factor kappa B subunit 1 gene product, and activation of target genes. Overexpression of this gene has been observed in some breast cancers and in some individuals with systemic lupus erythematosus (SLE). [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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