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Anti-FANCM monoclonal antibody
Pre-made anti-FANCM monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FANCM/FANCM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0831-Ab-1/ GM-Tg-hg-IP0831-Ab-2 | Anti-Human FANCM monoclonal antibody | Human |
| GM-Tg-rg-IP0831-Ab-1/ GM-Tg-rg-IP0831-Ab-2 | Anti-Rat FANCM monoclonal antibody | Rat |
| GM-Tg-mg-IP0831-Ab-1/ GM-Tg-mg-IP0831-Ab-2 | Anti-Mouse FANCM monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0831-Ab-1/ GM-Tg-cynog-IP0831-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FANCM monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0831-Ab-1/ GM-Tg-felg-IP0831-Ab-2 | Anti-Feline FANCM monoclonal antibody | Feline |
| GM-Tg-cang-IP0831-Ab-1/ GM-Tg-cang-IP0831-Ab-2 | Anti-Canine FANCM monoclonal antibody | Canine |
| GM-Tg-bovg-IP0831-Ab-1/ GM-Tg-bovg-IP0831-Ab-2 | Anti-Bovine FANCM monoclonal antibody | Bovine |
| GM-Tg-equg-IP0831-Ab-1/ GM-Tg-equg-IP0831-Ab-2 | Anti-Equine FANCM monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0831-Ab-1/ GM-Tg-hg-IP0831-Ab-2; GM-Tg-rg-IP0831-Ab-1/ GM-Tg-rg-IP0831-Ab-2; GM-Tg-mg-IP0831-Ab-1/ GM-Tg-mg-IP0831-Ab-2; GM-Tg-cynog-IP0831-Ab-1/ GM-Tg-cynog-IP0831-Ab-2; GM-Tg-felg-IP0831-Ab-1/ GM-Tg-felg-IP0831-Ab-2; GM-Tg-cang-IP0831-Ab-1/ GM-Tg-cang-IP0831-Ab-2; GM-Tg-bovg-IP0831-Ab-1/ GM-Tg-bovg-IP0831-Ab-2; GM-Tg-equg-IP0831-Ab-1/ GM-Tg-equg-IP0831-Ab-2 |
| Products Name | Anti-FANCM monoclonal antibody |
| Format | mab |
| Target Name | FANCM |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FANCM monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0831-Ag-1 | Recombinant multi-species FANCM/ FAAP250/ KIAA1596 protein |
Target information
| Target ID | GM-IP0831 |
| Target Name | FANCM |
| Gene ID | 57697,104806,314172,702513,480307,101086570,513626,100063761 |
| Gene Symbol and Synonyms | C730036B14Rik,D12Ertd364e,FAAP250,FANCM,KIAA1596,POF15,RGD1307897,SPGF28 |
| Uniprot Accession | Q8IYD8 |
| Uniprot Entry Name | FANCM_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000187790 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FANCM, gene name: FANCM, also named as FAAP250, KIAA1596, POF15, SPGF28. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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