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Anti-FIG4 monoclonal antibody
Pre-made anti-FIG4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FIG4/FIG4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0846-Ab-1/ GM-Tg-hg-IP0846-Ab-2 | Anti-Human FIG4 monoclonal antibody | Human |
| GM-Tg-rg-IP0846-Ab-1/ GM-Tg-rg-IP0846-Ab-2 | Anti-Rat FIG4 monoclonal antibody | Rat |
| GM-Tg-mg-IP0846-Ab-1/ GM-Tg-mg-IP0846-Ab-2 | Anti-Mouse FIG4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0846-Ab-1/ GM-Tg-cynog-IP0846-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FIG4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0846-Ab-1/ GM-Tg-felg-IP0846-Ab-2 | Anti-Feline FIG4 monoclonal antibody | Feline |
| GM-Tg-cang-IP0846-Ab-1/ GM-Tg-cang-IP0846-Ab-2 | Anti-Canine FIG4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0846-Ab-1/ GM-Tg-bovg-IP0846-Ab-2 | Anti-Bovine FIG4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0846-Ab-1/ GM-Tg-equg-IP0846-Ab-2 | Anti-Equine FIG4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0846-Ab-1/ GM-Tg-hg-IP0846-Ab-2; GM-Tg-rg-IP0846-Ab-1/ GM-Tg-rg-IP0846-Ab-2; GM-Tg-mg-IP0846-Ab-1/ GM-Tg-mg-IP0846-Ab-2; GM-Tg-cynog-IP0846-Ab-1/ GM-Tg-cynog-IP0846-Ab-2; GM-Tg-felg-IP0846-Ab-1/ GM-Tg-felg-IP0846-Ab-2; GM-Tg-cang-IP0846-Ab-1/ GM-Tg-cang-IP0846-Ab-2; GM-Tg-bovg-IP0846-Ab-1/ GM-Tg-bovg-IP0846-Ab-2; GM-Tg-equg-IP0846-Ab-1/ GM-Tg-equg-IP0846-Ab-2 |
| Products Name | Anti-FIG4 monoclonal antibody |
| Format | mab |
| Target Name | FIG4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FIG4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0846-Ag-1 | Recombinant multi-species FIG4/ ALS11/ BTOP protein |
| ORF Viral Vector | pGMLP001500 | human FIG4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001500 | human FIG4 Lentivirus particle |
Target information
| Target ID | GM-IP0846 |
| Target Name | FIG4 |
| Gene ID | 9896,103199,309855,699914,475023,101080288,534118,100066727 |
| Gene Symbol and Synonyms | A530089I17Rik,ALS11,BOP,BTOP,CMT4J,dJ249I4.1,FIG4,KIAA0274,RGD1311375,SAC3,YVS |
| Uniprot Accession | Q92562 |
| Uniprot Entry Name | FIG4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000112367 |
| Target Classification | N/A |
The target: FIG4, gene name: FIG4, also named as ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1. The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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