Anti-FXYD5 monoclonal antibody

Pre-made anti-FXYD5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to FXYD5/FXYD5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP0874-Ab-1/ GM-Tg-hg-IP0874-Ab-2Anti-Human FXYD5 monoclonal antibodyHuman
GM-Tg-rg-IP0874-Ab-1/ GM-Tg-rg-IP0874-Ab-2Anti-Rat FXYD5 monoclonal antibodyRat
GM-Tg-mg-IP0874-Ab-1/ GM-Tg-mg-IP0874-Ab-2Anti-Mouse FXYD5 monoclonal antibodyMouse
GM-Tg-cynog-IP0874-Ab-1/ GM-Tg-cynog-IP0874-Ab-2Anti-Cynomolgus/ Rhesus macaque FXYD5 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP0874-Ab-1/ GM-Tg-felg-IP0874-Ab-2Anti-Feline FXYD5 monoclonal antibodyFeline
GM-Tg-cang-IP0874-Ab-1/ GM-Tg-cang-IP0874-Ab-2Anti-Canine FXYD5 monoclonal antibodyCanine
GM-Tg-bovg-IP0874-Ab-1/ GM-Tg-bovg-IP0874-Ab-2Anti-Bovine FXYD5 monoclonal antibodyBovine
GM-Tg-equg-IP0874-Ab-1/ GM-Tg-equg-IP0874-Ab-2Anti-Equine FXYD5 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP0874-Ab-1/ GM-Tg-hg-IP0874-Ab-2; GM-Tg-rg-IP0874-Ab-1/ GM-Tg-rg-IP0874-Ab-2;
GM-Tg-mg-IP0874-Ab-1/ GM-Tg-mg-IP0874-Ab-2; GM-Tg-cynog-IP0874-Ab-1/ GM-Tg-cynog-IP0874-Ab-2;
GM-Tg-felg-IP0874-Ab-1/ GM-Tg-felg-IP0874-Ab-2; GM-Tg-cang-IP0874-Ab-1/ GM-Tg-cang-IP0874-Ab-2;
GM-Tg-bovg-IP0874-Ab-1/ GM-Tg-bovg-IP0874-Ab-2; GM-Tg-equg-IP0874-Ab-1/ GM-Tg-equg-IP0874-Ab-2
Products NameAnti-FXYD5 monoclonal antibody
Formatmab
Target NameFXYD5
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-FXYD5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP0874-Ag-1Recombinant multi-species FXYD5/ DYSAD/ HSPC113 protein


    Target information

    Target IDGM-IP0874
    Target NameFXYD5
    Gene ID53827,18301,60338,718467,612666,102901796,505584,100059073
    Gene Symbol and SynonymsDYSAD,Dysadherin,EF-8,FXYD5,HSPC113,IWU1,KCT1,OIT2,PRO6241,RIC
    Uniprot AccessionQ96DB9,P59647
    Uniprot Entry NameFXYD5_HUMAN,FXYD5_RAT
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000089327
    Target ClassificationN/A

    The target: FXYD5, gene name: FXYD5, also named as DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected]., Sep 2009].



    About Gmab

    GDU
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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.