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Anti-FXYD5 monoclonal antibody
Pre-made anti-FXYD5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to FXYD5/FXYD5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0874-Ab-1/ GM-Tg-hg-IP0874-Ab-2 | Anti-Human FXYD5 monoclonal antibody | Human |
| GM-Tg-rg-IP0874-Ab-1/ GM-Tg-rg-IP0874-Ab-2 | Anti-Rat FXYD5 monoclonal antibody | Rat |
| GM-Tg-mg-IP0874-Ab-1/ GM-Tg-mg-IP0874-Ab-2 | Anti-Mouse FXYD5 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0874-Ab-1/ GM-Tg-cynog-IP0874-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FXYD5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0874-Ab-1/ GM-Tg-felg-IP0874-Ab-2 | Anti-Feline FXYD5 monoclonal antibody | Feline |
| GM-Tg-cang-IP0874-Ab-1/ GM-Tg-cang-IP0874-Ab-2 | Anti-Canine FXYD5 monoclonal antibody | Canine |
| GM-Tg-bovg-IP0874-Ab-1/ GM-Tg-bovg-IP0874-Ab-2 | Anti-Bovine FXYD5 monoclonal antibody | Bovine |
| GM-Tg-equg-IP0874-Ab-1/ GM-Tg-equg-IP0874-Ab-2 | Anti-Equine FXYD5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0874-Ab-1/ GM-Tg-hg-IP0874-Ab-2; GM-Tg-rg-IP0874-Ab-1/ GM-Tg-rg-IP0874-Ab-2; GM-Tg-mg-IP0874-Ab-1/ GM-Tg-mg-IP0874-Ab-2; GM-Tg-cynog-IP0874-Ab-1/ GM-Tg-cynog-IP0874-Ab-2; GM-Tg-felg-IP0874-Ab-1/ GM-Tg-felg-IP0874-Ab-2; GM-Tg-cang-IP0874-Ab-1/ GM-Tg-cang-IP0874-Ab-2; GM-Tg-bovg-IP0874-Ab-1/ GM-Tg-bovg-IP0874-Ab-2; GM-Tg-equg-IP0874-Ab-1/ GM-Tg-equg-IP0874-Ab-2 |
| Products Name | Anti-FXYD5 monoclonal antibody |
| Format | mab |
| Target Name | FXYD5 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-FXYD5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0874-Ag-1 | Recombinant multi-species FXYD5/ DYSAD/ HSPC113 protein |
Target information
| Target ID | GM-IP0874 |
| Target Name | FXYD5 |
| Gene ID | 53827,18301,60338,718467,612666,102901796,505584,100059073 |
| Gene Symbol and Synonyms | DYSAD,Dysadherin,EF-8,FXYD5,HSPC113,IWU1,KCT1,OIT2,PRO6241,RIC |
| Uniprot Accession | Q96DB9,P59647 |
| Uniprot Entry Name | FXYD5_HUMAN,FXYD5_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000089327 |
| Target Classification | N/A |
The target: FXYD5, gene name: FXYD5, also named as DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., [email protected]., Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
