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Anti-HELZ monoclonal antibody
Pre-made anti-HELZ monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HELZ/HELZ products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP0958-Ab-1/ GM-Tg-hg-IP0958-Ab-2 | Anti-Human HELZ monoclonal antibody | Human |
| GM-Tg-rg-IP0958-Ab-1/ GM-Tg-rg-IP0958-Ab-2 | Anti-Rat HELZ monoclonal antibody | Rat |
| GM-Tg-mg-IP0958-Ab-1/ GM-Tg-mg-IP0958-Ab-2 | Anti-Mouse HELZ monoclonal antibody | Mouse |
| GM-Tg-cynog-IP0958-Ab-1/ GM-Tg-cynog-IP0958-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HELZ monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP0958-Ab-1/ GM-Tg-felg-IP0958-Ab-2 | Anti-Feline HELZ monoclonal antibody | Feline |
| GM-Tg-cang-IP0958-Ab-1/ GM-Tg-cang-IP0958-Ab-2 | Anti-Canine HELZ monoclonal antibody | Canine |
| GM-Tg-bovg-IP0958-Ab-1/ GM-Tg-bovg-IP0958-Ab-2 | Anti-Bovine HELZ monoclonal antibody | Bovine |
| GM-Tg-equg-IP0958-Ab-1/ GM-Tg-equg-IP0958-Ab-2 | Anti-Equine HELZ monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP0958-Ab-1/ GM-Tg-hg-IP0958-Ab-2; GM-Tg-rg-IP0958-Ab-1/ GM-Tg-rg-IP0958-Ab-2; GM-Tg-mg-IP0958-Ab-1/ GM-Tg-mg-IP0958-Ab-2; GM-Tg-cynog-IP0958-Ab-1/ GM-Tg-cynog-IP0958-Ab-2; GM-Tg-felg-IP0958-Ab-1/ GM-Tg-felg-IP0958-Ab-2; GM-Tg-cang-IP0958-Ab-1/ GM-Tg-cang-IP0958-Ab-2; GM-Tg-bovg-IP0958-Ab-1/ GM-Tg-bovg-IP0958-Ab-2; GM-Tg-equg-IP0958-Ab-1/ GM-Tg-equg-IP0958-Ab-2 |
| Products Name | Anti-HELZ monoclonal antibody |
| Format | mab |
| Target Name | HELZ |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HELZ monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP0958-Ag-1 | Recombinant multi-species HELZ/ DHRC/ DRHC protein |
Target information
| Target ID | GM-IP0958 |
| Target Name | HELZ |
| Gene ID | 9931,78455,287773,718729,490907,101101269,539501,100053580 |
| Gene Symbol and Synonyms | 3110078M01Rik,9430093I07Rik,9630002H22Rik,DHRC,DRHC,HELZ,HUMORF5 |
| Uniprot Accession | P42694 |
| Uniprot Entry Name | HELZ_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000198265 |
| Target Classification | N/A |
The target: HELZ, gene name: HELZ, also named as DHRC, DRHC, HUMORF5. HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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