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Anti-KALRN monoclonal antibody
Pre-made anti-KALRN monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KALRN/KALRN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1034-Ab-1/ GM-Tg-hg-IP1034-Ab-2 | Anti-Human KALRN monoclonal antibody | Human |
| GM-Tg-rg-IP1034-Ab-1/ GM-Tg-rg-IP1034-Ab-2 | Anti-Rat KALRN monoclonal antibody | Rat |
| GM-Tg-mg-IP1034-Ab-1/ GM-Tg-mg-IP1034-Ab-2 | Anti-Mouse KALRN monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1034-Ab-1/ GM-Tg-cynog-IP1034-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KALRN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1034-Ab-1/ GM-Tg-felg-IP1034-Ab-2 | Anti-Feline KALRN monoclonal antibody | Feline |
| GM-Tg-cang-IP1034-Ab-1/ GM-Tg-cang-IP1034-Ab-2 | Anti-Canine KALRN monoclonal antibody | Canine |
| GM-Tg-bovg-IP1034-Ab-1/ GM-Tg-bovg-IP1034-Ab-2 | Anti-Bovine KALRN monoclonal antibody | Bovine |
| GM-Tg-equg-IP1034-Ab-1/ GM-Tg-equg-IP1034-Ab-2 | Anti-Equine KALRN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1034-Ab-1/ GM-Tg-hg-IP1034-Ab-2; GM-Tg-rg-IP1034-Ab-1/ GM-Tg-rg-IP1034-Ab-2; GM-Tg-mg-IP1034-Ab-1/ GM-Tg-mg-IP1034-Ab-2; GM-Tg-cynog-IP1034-Ab-1/ GM-Tg-cynog-IP1034-Ab-2; GM-Tg-felg-IP1034-Ab-1/ GM-Tg-felg-IP1034-Ab-2; GM-Tg-cang-IP1034-Ab-1/ GM-Tg-cang-IP1034-Ab-2; GM-Tg-bovg-IP1034-Ab-1/ GM-Tg-bovg-IP1034-Ab-2; GM-Tg-equg-IP1034-Ab-1/ GM-Tg-equg-IP1034-Ab-2 |
| Products Name | Anti-KALRN monoclonal antibody |
| Format | mab |
| Target Name | KALRN |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KALRN monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1034-Ag-1 | Recombinant multi-species KALRN/ ARHGEF24/ CHD5 protein |
Target information
| Target ID | GM-IP1034 |
| Target Name | KALRN |
| Gene ID | 8997,545156,84009,715567,101094783,540675,100060560 |
| Gene Symbol and Synonyms | 2210407G14Rik,ARHGEF24,CHD5,CHDS5,DUET,DUO,E530005C20Rik,Gm539,HAPIP,Kalirin,KALNC2,KALRN,TRAD |
| Uniprot Accession | O60229,P97924 |
| Uniprot Entry Name | KALRN_HUMAN,KALRN_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000160145 |
| Target Classification | N/A |
The target: KALRN, gene name: KALRN, also named as ARHGEF24, CHD5, CHDS5, DUET, DUO, HAPIP, TRAD. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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