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Anti-KCNE4 monoclonal antibody
Pre-made anti-KCNE4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KCNE4/KCNE4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1036-Ab-1/ GM-Tg-hg-IP1036-Ab-2 | Anti-Human KCNE4 monoclonal antibody | Human |
| GM-Tg-rg-IP1036-Ab-1/ GM-Tg-rg-IP1036-Ab-2 | Anti-Rat KCNE4 monoclonal antibody | Rat |
| GM-Tg-mg-IP1036-Ab-1/ GM-Tg-mg-IP1036-Ab-2 | Anti-Mouse KCNE4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1036-Ab-1/ GM-Tg-cynog-IP1036-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KCNE4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1036-Ab-1/ GM-Tg-felg-IP1036-Ab-2 | Anti-Feline KCNE4 monoclonal antibody | Feline |
| GM-Tg-cang-IP1036-Ab-1/ GM-Tg-cang-IP1036-Ab-2 | Anti-Canine KCNE4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1036-Ab-1/ GM-Tg-bovg-IP1036-Ab-2 | Anti-Bovine KCNE4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1036-Ab-1/ GM-Tg-equg-IP1036-Ab-2 | Anti-Equine KCNE4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1036-Ab-1/ GM-Tg-hg-IP1036-Ab-2; GM-Tg-rg-IP1036-Ab-1/ GM-Tg-rg-IP1036-Ab-2; GM-Tg-mg-IP1036-Ab-1/ GM-Tg-mg-IP1036-Ab-2; GM-Tg-cynog-IP1036-Ab-1/ GM-Tg-cynog-IP1036-Ab-2; GM-Tg-felg-IP1036-Ab-1/ GM-Tg-felg-IP1036-Ab-2; GM-Tg-cang-IP1036-Ab-1/ GM-Tg-cang-IP1036-Ab-2; GM-Tg-bovg-IP1036-Ab-1/ GM-Tg-bovg-IP1036-Ab-2; GM-Tg-equg-IP1036-Ab-1/ GM-Tg-equg-IP1036-Ab-2 |
| Products Name | Anti-KCNE4 monoclonal antibody |
| Format | mab |
| Target Name | KCNE4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KCNE4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1036-Ag-1 | Recombinant multi-species KCNE4/ MIRP3 protein |
| ORF Viral Vector | pGMLP000918 | human KCNE4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000918 | human KCNE4 Lentivirus particle |
| ORF Viral Vector | pGMLPm000263 | mouse Kcne4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000263 | mouse Kcne4 Lentivirus particle |
Target information
| Target ID | GM-IP1036 |
| Target Name | KCNE4 |
| Gene ID | 23704,57814,367302,723519,488549,101083535,615761,100061005 |
| Gene Symbol and Synonyms | KCNE4,MIRP3 |
| Uniprot Accession | Q8WWG9 |
| Uniprot Entry Name | KCNE4_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152049 |
| Target Classification | N/A |
The target: KCNE4, gene name: KCNE4, also named as MIRP3. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the embryo and in adult uterus. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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