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Anti-KDELR2 monoclonal antibody
Pre-made anti-KDELR2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KDELR2/KDELR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1042-Ab-1/ GM-Tg-hg-IP1042-Ab-2 | Anti-Human KDELR2 monoclonal antibody | Human |
| GM-Tg-rg-IP1042-Ab-1/ GM-Tg-rg-IP1042-Ab-2 | Anti-Rat KDELR2 monoclonal antibody | Rat |
| GM-Tg-mg-IP1042-Ab-1/ GM-Tg-mg-IP1042-Ab-2 | Anti-Mouse KDELR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1042-Ab-1/ GM-Tg-cynog-IP1042-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KDELR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1042-Ab-1/ GM-Tg-felg-IP1042-Ab-2 | Anti-Feline KDELR2 monoclonal antibody | Feline |
| GM-Tg-cang-IP1042-Ab-1/ GM-Tg-cang-IP1042-Ab-2 | Anti-Canine KDELR2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1042-Ab-1/ GM-Tg-bovg-IP1042-Ab-2 | Anti-Bovine KDELR2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1042-Ab-1/ GM-Tg-equg-IP1042-Ab-2 | Anti-Equine KDELR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1042-Ab-1/ GM-Tg-hg-IP1042-Ab-2; GM-Tg-rg-IP1042-Ab-1/ GM-Tg-rg-IP1042-Ab-2; GM-Tg-mg-IP1042-Ab-1/ GM-Tg-mg-IP1042-Ab-2; GM-Tg-cynog-IP1042-Ab-1/ GM-Tg-cynog-IP1042-Ab-2; GM-Tg-felg-IP1042-Ab-1/ GM-Tg-felg-IP1042-Ab-2; GM-Tg-cang-IP1042-Ab-1/ GM-Tg-cang-IP1042-Ab-2; GM-Tg-bovg-IP1042-Ab-1/ GM-Tg-bovg-IP1042-Ab-2; GM-Tg-equg-IP1042-Ab-1/ GM-Tg-equg-IP1042-Ab-2 |
| Products Name | Anti-KDELR2 monoclonal antibody |
| Format | mab |
| Target Name | KDELR2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KDELR2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1042-Ag-1 | Recombinant multi-species ERD22/ KDELR2/ ELP-1 protein |
| ORF Viral Vector | vGMLP003266 | human KDELR2 Lentivirus particle |
| ORF Viral Vector | pGMLP003266 | human KDELR2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002242 | mouse Kdelr2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002242 | mouse Kdelr2 Lentivirus particle |
Target information
| Target ID | GM-IP1042 |
| Target Name | KDELR2 |
| Gene ID | 11014,66913,304290,704335,612839,101100774,531676,102150227 |
| Gene Symbol and Synonyms | 1110007A14Rik,ELP-1,ELP1,ERD2.2,KDELR1,KDELR2,OI21 |
| Uniprot Accession | P33947,Q5U305,Q2KJ37 |
| Uniprot Entry Name | ERD22_HUMAN,ERD22_RAT,ERD22_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136240 |
| Target Classification | N/A |
The target: KDELR2, gene name: KDELR2, also named as ELP-1, ERD2.2. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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