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Anti-KIDINS220 monoclonal antibody
Pre-made anti-KIDINS220 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KIDINS220/KIDINS220 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1053-Ab-1/ GM-Tg-hg-IP1053-Ab-2 | Anti-Human KIDINS220 monoclonal antibody | Human |
| GM-Tg-rg-IP1053-Ab-1/ GM-Tg-rg-IP1053-Ab-2 | Anti-Rat KIDINS220 monoclonal antibody | Rat |
| GM-Tg-mg-IP1053-Ab-1/ GM-Tg-mg-IP1053-Ab-2 | Anti-Mouse KIDINS220 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1053-Ab-1/ GM-Tg-cynog-IP1053-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KIDINS220 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1053-Ab-1/ GM-Tg-felg-IP1053-Ab-2 | Anti-Feline KIDINS220 monoclonal antibody | Feline |
| GM-Tg-cang-IP1053-Ab-1/ GM-Tg-cang-IP1053-Ab-2 | Anti-Canine KIDINS220 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1053-Ab-1/ GM-Tg-bovg-IP1053-Ab-2 | Anti-Bovine KIDINS220 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1053-Ab-1/ GM-Tg-equg-IP1053-Ab-2 | Anti-Equine KIDINS220 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1053-Ab-1/ GM-Tg-hg-IP1053-Ab-2; GM-Tg-rg-IP1053-Ab-1/ GM-Tg-rg-IP1053-Ab-2; GM-Tg-mg-IP1053-Ab-1/ GM-Tg-mg-IP1053-Ab-2; GM-Tg-cynog-IP1053-Ab-1/ GM-Tg-cynog-IP1053-Ab-2; GM-Tg-felg-IP1053-Ab-1/ GM-Tg-felg-IP1053-Ab-2; GM-Tg-cang-IP1053-Ab-1/ GM-Tg-cang-IP1053-Ab-2; GM-Tg-bovg-IP1053-Ab-1/ GM-Tg-bovg-IP1053-Ab-2; GM-Tg-equg-IP1053-Ab-1/ GM-Tg-equg-IP1053-Ab-2 |
| Products Name | Anti-KIDINS220 monoclonal antibody |
| Format | mab |
| Target Name | KIDINS220 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KIDINS220 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1053-Ag-1 | Recombinant multi-species KDIS/ KIDINS220/ ARMS protein |
Target information
| Target ID | GM-IP1053 |
| Target Name | KIDINS220 |
| Gene ID | 57498,77480,116478,693522,475657,101096227,536267,100057204 |
| Gene Symbol and Synonyms | 3110039L19Rik,ARMS,C330002I19Rik,KIDINS220,mKIAA1250,SINO,VENARG |
| Uniprot Accession | Q9ULH0,Q9EQG6 |
| Uniprot Entry Name | KDIS_HUMAN,KDIS_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000134313 |
| Target Classification | N/A |
The target: KIDINS220, gene name: KIDINS220, also named as ARMS, SINO. This gene encodes a transmembrane protein that is preferentially expressed in the nervous system where it controls neuronal cell survival, differentiation into exons and dendrites, and synaptic plasticity. The encoded protein interacts with membrane receptors, cytosolic signaling components, and cytoskeletal proteins, serving as a scaffold that mediates crosstalk between the neurotrophin pathway and several other intracellular signaling pathways. Aberrant expression of this gene is associated with the onset of various neuropsychiatric disorders and neurodegenerative diseases, including Alzheimer's disease. Naturally occurring mutations in this gene are associated with a syndrome characterized by spastic paraplegia, intellectual disability, nystagmus and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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