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Anti-LARGE1 monoclonal antibody
Pre-made anti-LARGE1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LARGE1/LARGE1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1068-Ab-1/ GM-Tg-hg-IP1068-Ab-2 | Anti-Human LARGE1 monoclonal antibody | Human |
| GM-Tg-rg-IP1068-Ab-1/ GM-Tg-rg-IP1068-Ab-2 | Anti-Rat LARGE1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1068-Ab-1/ GM-Tg-mg-IP1068-Ab-2 | Anti-Mouse LARGE1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1068-Ab-1/ GM-Tg-cynog-IP1068-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LARGE1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1068-Ab-1/ GM-Tg-felg-IP1068-Ab-2 | Anti-Feline LARGE1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1068-Ab-1/ GM-Tg-cang-IP1068-Ab-2 | Anti-Canine LARGE1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1068-Ab-1/ GM-Tg-bovg-IP1068-Ab-2 | Anti-Bovine LARGE1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1068-Ab-1/ GM-Tg-equg-IP1068-Ab-2 | Anti-Equine LARGE1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1068-Ab-1/ GM-Tg-hg-IP1068-Ab-2; GM-Tg-rg-IP1068-Ab-1/ GM-Tg-rg-IP1068-Ab-2; GM-Tg-mg-IP1068-Ab-1/ GM-Tg-mg-IP1068-Ab-2; GM-Tg-cynog-IP1068-Ab-1/ GM-Tg-cynog-IP1068-Ab-2; GM-Tg-felg-IP1068-Ab-1/ GM-Tg-felg-IP1068-Ab-2; GM-Tg-cang-IP1068-Ab-1/ GM-Tg-cang-IP1068-Ab-2; GM-Tg-bovg-IP1068-Ab-1/ GM-Tg-bovg-IP1068-Ab-2; GM-Tg-equg-IP1068-Ab-1/ GM-Tg-equg-IP1068-Ab-2 |
| Products Name | Anti-LARGE1 monoclonal antibody |
| Format | mab |
| Target Name | LARGE1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LARGE1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1068-Ag-1 | Recombinant multi-species LARG1/ LARGE1/ LARGE protein |
Target information
| Target ID | GM-IP1068 |
| Target Name | LARGE1 |
| Gene ID | 9215,16795,361368,717403,474521,101091463,506466,100068935 |
| Gene Symbol and Synonyms | BPFD#36,enr,fg,froggy,Gyltl1a,LARGE,LARGE1,Mbp-1,Mbp1,MDC1D,MDDGA6,MDDGB6,myd |
| Uniprot Accession | O95461 |
| Uniprot Entry Name | LARG1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000133424 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LARGE1, gene name: LARGE1, also named as LARGE, MDC1D, MDDGA6, MDDGB6. This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. The protein encoded by this gene is the glycotransferase that adds the final xylose and glucuronic acid to alpha-dystroglycan and thereby allows alpha-dystroglycan to bind ligands including laminin 211 and neurexin. Mutations in this gene cause several forms of congenital muscular dystrophy characterized by cognitive disability and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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