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Anti-LBR monoclonal antibody
Pre-made anti-LBR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LBR/LBR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1071-Ab-1/ GM-Tg-hg-IP1071-Ab-2 | Anti-Human LBR monoclonal antibody | Human |
| GM-Tg-rg-IP1071-Ab-1/ GM-Tg-rg-IP1071-Ab-2 | Anti-Rat LBR monoclonal antibody | Rat |
| GM-Tg-mg-IP1071-Ab-1/ GM-Tg-mg-IP1071-Ab-2 | Anti-Mouse LBR monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1071-Ab-1/ GM-Tg-cynog-IP1071-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LBR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1071-Ab-1/ GM-Tg-felg-IP1071-Ab-2 | Anti-Feline LBR monoclonal antibody | Feline |
| GM-Tg-cang-IP1071-Ab-1/ GM-Tg-cang-IP1071-Ab-2 | Anti-Canine LBR monoclonal antibody | Canine |
| GM-Tg-bovg-IP1071-Ab-1/ GM-Tg-bovg-IP1071-Ab-2 | Anti-Bovine LBR monoclonal antibody | Bovine |
| GM-Tg-equg-IP1071-Ab-1/ GM-Tg-equg-IP1071-Ab-2 | Anti-Equine LBR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1071-Ab-1/ GM-Tg-hg-IP1071-Ab-2; GM-Tg-rg-IP1071-Ab-1/ GM-Tg-rg-IP1071-Ab-2; GM-Tg-mg-IP1071-Ab-1/ GM-Tg-mg-IP1071-Ab-2; GM-Tg-cynog-IP1071-Ab-1/ GM-Tg-cynog-IP1071-Ab-2; GM-Tg-felg-IP1071-Ab-1/ GM-Tg-felg-IP1071-Ab-2; GM-Tg-cang-IP1071-Ab-1/ GM-Tg-cang-IP1071-Ab-2; GM-Tg-bovg-IP1071-Ab-1/ GM-Tg-bovg-IP1071-Ab-2; GM-Tg-equg-IP1071-Ab-1/ GM-Tg-equg-IP1071-Ab-2 |
| Products Name | Anti-LBR monoclonal antibody |
| Format | mab |
| Target Name | LBR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LBR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1071-Ag-1 | Recombinant multi-species LBR/ DHCR14B/ LMN2R protein |
| ORF Viral Vector | vGMAP000472 | Human LBR Adenovirus particle |
| ORF Viral Vector | pGMAP000472 | Human LBR Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002018 | mouse Lbr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002018 | mouse Lbr Lentivirus particle |
Target information
| Target ID | GM-IP1071 |
| Target Name | LBR |
| Gene ID | 3930,98386,89789,700801,490391,101085014,509348,100056997 |
| Gene Symbol and Synonyms | C14SR,DHCR14B,ic,LBR,LMN2R,Nbp60,PHA,PHASK,TDRD18 |
| Uniprot Accession | Q14739,O08984 |
| Uniprot Entry Name | LBR_HUMAN,LBR_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000143815 |
| Target Classification | N/A |
The target: LBR, gene name: LBR, also named as DHCR14B, LMN2R, PHA, PHASK, TDRD18. The protein encoded by this gene belongs to the ERG4/ERG24 family. It localized in the nuclear envelope inner membrane and anchors the lamina and the heterochromatin to the membrane. It may mediate interaction between chromatin and lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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