Anti-LEMD3 monoclonal antibody

Pre-made anti-LEMD3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to LEMD3/LEMD3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1078-Ab-1/ GM-Tg-hg-IP1078-Ab-2Anti-Human LEMD3 monoclonal antibodyHuman
GM-Tg-rg-IP1078-Ab-1/ GM-Tg-rg-IP1078-Ab-2Anti-Rat LEMD3 monoclonal antibodyRat
GM-Tg-mg-IP1078-Ab-1/ GM-Tg-mg-IP1078-Ab-2Anti-Mouse LEMD3 monoclonal antibodyMouse
GM-Tg-cynog-IP1078-Ab-1/ GM-Tg-cynog-IP1078-Ab-2Anti-Cynomolgus/ Rhesus macaque LEMD3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1078-Ab-1/ GM-Tg-felg-IP1078-Ab-2Anti-Feline LEMD3 monoclonal antibodyFeline
GM-Tg-cang-IP1078-Ab-1/ GM-Tg-cang-IP1078-Ab-2Anti-Canine LEMD3 monoclonal antibodyCanine
GM-Tg-bovg-IP1078-Ab-1/ GM-Tg-bovg-IP1078-Ab-2Anti-Bovine LEMD3 monoclonal antibodyBovine
GM-Tg-equg-IP1078-Ab-1/ GM-Tg-equg-IP1078-Ab-2Anti-Equine LEMD3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1078-Ab-1/ GM-Tg-hg-IP1078-Ab-2; GM-Tg-rg-IP1078-Ab-1/ GM-Tg-rg-IP1078-Ab-2;
GM-Tg-mg-IP1078-Ab-1/ GM-Tg-mg-IP1078-Ab-2; GM-Tg-cynog-IP1078-Ab-1/ GM-Tg-cynog-IP1078-Ab-2;
GM-Tg-felg-IP1078-Ab-1/ GM-Tg-felg-IP1078-Ab-2; GM-Tg-cang-IP1078-Ab-1/ GM-Tg-cang-IP1078-Ab-2;
GM-Tg-bovg-IP1078-Ab-1/ GM-Tg-bovg-IP1078-Ab-2; GM-Tg-equg-IP1078-Ab-1/ GM-Tg-equg-IP1078-Ab-2
Products NameAnti-LEMD3 monoclonal antibody
Formatmab
Target NameLEMD3
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-LEMD3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1078-Ag-1Recombinant multi-species MAN1/ LEMD3 protein


    Target information

    Target IDGM-IP1078
    Target NameLEMD3
    Gene ID23592,380664,680066,717597,608380,101092198,530659,100057180
    Gene Symbol and SynonymsLEMD3,MAN1,RGD1561001
    Uniprot AccessionQ9Y2U8
    Uniprot Entry NameMAN1_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000174106
    Target ClassificationN/A

    The target: LEMD3, gene name: LEMD3, also named as MAN1. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.