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Anti-LMAN1 monoclonal antibody
Pre-made anti-LMAN1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LMAN1/LMAN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1089-Ab-1/ GM-Tg-hg-IP1089-Ab-2 | Anti-Human LMAN1 monoclonal antibody | Human |
| GM-Tg-rg-IP1089-Ab-1/ GM-Tg-rg-IP1089-Ab-2 | Anti-Rat LMAN1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1089-Ab-1/ GM-Tg-mg-IP1089-Ab-2 | Anti-Mouse LMAN1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1089-Ab-1/ GM-Tg-cynog-IP1089-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LMAN1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1089-Ab-1/ GM-Tg-felg-IP1089-Ab-2 | Anti-Feline LMAN1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1089-Ab-1/ GM-Tg-cang-IP1089-Ab-2 | Anti-Canine LMAN1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1089-Ab-1/ GM-Tg-bovg-IP1089-Ab-2 | Anti-Bovine LMAN1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1089-Ab-1/ GM-Tg-equg-IP1089-Ab-2 | Anti-Equine LMAN1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1089-Ab-1/ GM-Tg-hg-IP1089-Ab-2; GM-Tg-rg-IP1089-Ab-1/ GM-Tg-rg-IP1089-Ab-2; GM-Tg-mg-IP1089-Ab-1/ GM-Tg-mg-IP1089-Ab-2; GM-Tg-cynog-IP1089-Ab-1/ GM-Tg-cynog-IP1089-Ab-2; GM-Tg-felg-IP1089-Ab-1/ GM-Tg-felg-IP1089-Ab-2; GM-Tg-cang-IP1089-Ab-1/ GM-Tg-cang-IP1089-Ab-2; GM-Tg-bovg-IP1089-Ab-1/ GM-Tg-bovg-IP1089-Ab-2; GM-Tg-equg-IP1089-Ab-1/ GM-Tg-equg-IP1089-Ab-2 |
| Products Name | Anti-LMAN1 monoclonal antibody |
| Format | mab |
| Target Name | LMAN1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LMAN1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1089-Ag-1 | Recombinant multi-species LMAN1/ ERGIC-53/ ERGIC53 protein |
| ORF Viral Vector | pGMLP001683 | human LMAN1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001683 | human LMAN1 Lentivirus particle |
| ORF Viral Vector | pGMLPm002684 | mouse Lman1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002684 | mouse Lman1 Lentivirus particle |
Target information
| Target ID | GM-IP1089 |
| Target Name | LMAN1 |
| Gene ID | 3998,70361,116666,697449,476186,101080833,511649,100050262 |
| Gene Symbol and Synonyms | 2610020P13Rik,C730041J05,ERGIC-53,ERGIC53,F5F8D,FMFD1,gp58,LMAN1,MCFD1,MR60,P58 |
| Uniprot Accession | P49257,Q62902 |
| Uniprot Entry Name | LMAN1_HUMAN,LMAN1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000074695 |
| Target Classification | N/A |
The target: LMAN1, gene name: LMAN1, also named as ERGIC-53, ERGIC53, F5F8D, FMFD1, MCFD1, MR60, gp58. The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency. [provided by RefSeq, Jul 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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