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Anti-LMNA monoclonal antibody
Pre-made anti-LMNA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to LMNA/LMNA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1097-Ab-1/ GM-Tg-hg-IP1097-Ab-2 | Anti-Human LMNA monoclonal antibody | Human |
| GM-Tg-rg-IP1097-Ab-1/ GM-Tg-rg-IP1097-Ab-2 | Anti-Rat LMNA monoclonal antibody | Rat |
| GM-Tg-mg-IP1097-Ab-1/ GM-Tg-mg-IP1097-Ab-2 | Anti-Mouse LMNA monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1097-Ab-1/ GM-Tg-cynog-IP1097-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LMNA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1097-Ab-1/ GM-Tg-felg-IP1097-Ab-2 | Anti-Feline LMNA monoclonal antibody | Feline |
| GM-Tg-cang-IP1097-Ab-1/ GM-Tg-cang-IP1097-Ab-2 | Anti-Canine LMNA monoclonal antibody | Canine |
| GM-Tg-bovg-IP1097-Ab-1/ GM-Tg-bovg-IP1097-Ab-2 | Anti-Bovine LMNA monoclonal antibody | Bovine |
| GM-Tg-equg-IP1097-Ab-1/ GM-Tg-equg-IP1097-Ab-2 | Anti-Equine LMNA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1097-Ab-1/ GM-Tg-hg-IP1097-Ab-2; GM-Tg-rg-IP1097-Ab-1/ GM-Tg-rg-IP1097-Ab-2; GM-Tg-mg-IP1097-Ab-1/ GM-Tg-mg-IP1097-Ab-2; GM-Tg-cynog-IP1097-Ab-1/ GM-Tg-cynog-IP1097-Ab-2; GM-Tg-felg-IP1097-Ab-1/ GM-Tg-felg-IP1097-Ab-2; GM-Tg-cang-IP1097-Ab-1/ GM-Tg-cang-IP1097-Ab-2; GM-Tg-bovg-IP1097-Ab-1/ GM-Tg-bovg-IP1097-Ab-2; GM-Tg-equg-IP1097-Ab-1/ GM-Tg-equg-IP1097-Ab-2 |
| Products Name | Anti-LMNA monoclonal antibody |
| Format | mab |
| Target Name | LMNA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-LMNA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1097-Ag-1 | Recombinant multi-species LMNA/ CDCD1/ CDDC protein |
| ORF Viral Vector | pGMAP000512 | Human LMNA Adenovirus plasmid |
| ORF Viral Vector | vGMLV000785 | human LMNA Lentivirus particle |
| ORF Viral Vector | vGMAP000512 | Human LMNA Adenovirus particle |
| ORF Viral Vector | pGMLV000785 | human LMNA Lentivirus plasmid |
| ORF Viral Vector | pGMAD000419 | house mouse Lmna Adenovirus plasmid |
| ORF Viral Vector | vGMAD000419 | house mouse Lmna Adenovirus particle |
Target information
| Target ID | GM-IP1097 |
| Target Name | LMNA |
| Gene ID | 4000,16905,60374,719414,480124,101086199,404144,100057663 |
| Gene Symbol and Synonyms | CDCD1,CDDC,CMD1A,CMT2B1,Dhe,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNA,LMNC,LMNL1,MADA,PRO1 |
| Uniprot Accession | P02545,P48679 |
| Uniprot Entry Name | LMNA_HUMAN,LMNA_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000160789 |
| Target Classification | N/A |
The target: LMNA, gene name: LMNA, also named as CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, MADA, PRO1. The protein encoded by this gene is part of the nuclear lamina, a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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