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Anti-MFN2 monoclonal antibody
Pre-made anti-MFN2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MFN2/MFN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1173-Ab-1/ GM-Tg-hg-IP1173-Ab-2 | Anti-Human MFN2 monoclonal antibody | Human |
| GM-Tg-rg-IP1173-Ab-1/ GM-Tg-rg-IP1173-Ab-2 | Anti-Rat MFN2 monoclonal antibody | Rat |
| GM-Tg-mg-IP1173-Ab-1/ GM-Tg-mg-IP1173-Ab-2 | Anti-Mouse MFN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1173-Ab-1/ GM-Tg-cynog-IP1173-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MFN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1173-Ab-1/ GM-Tg-felg-IP1173-Ab-2 | Anti-Feline MFN2 monoclonal antibody | Feline |
| GM-Tg-cang-IP1173-Ab-1/ GM-Tg-cang-IP1173-Ab-2 | Anti-Canine MFN2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1173-Ab-1/ GM-Tg-bovg-IP1173-Ab-2 | Anti-Bovine MFN2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1173-Ab-1/ GM-Tg-equg-IP1173-Ab-2 | Anti-Equine MFN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1173-Ab-1/ GM-Tg-hg-IP1173-Ab-2; GM-Tg-rg-IP1173-Ab-1/ GM-Tg-rg-IP1173-Ab-2; GM-Tg-mg-IP1173-Ab-1/ GM-Tg-mg-IP1173-Ab-2; GM-Tg-cynog-IP1173-Ab-1/ GM-Tg-cynog-IP1173-Ab-2; GM-Tg-felg-IP1173-Ab-1/ GM-Tg-felg-IP1173-Ab-2; GM-Tg-cang-IP1173-Ab-1/ GM-Tg-cang-IP1173-Ab-2; GM-Tg-bovg-IP1173-Ab-1/ GM-Tg-bovg-IP1173-Ab-2; GM-Tg-equg-IP1173-Ab-1/ GM-Tg-equg-IP1173-Ab-2 |
| Products Name | Anti-MFN2 monoclonal antibody |
| Format | mab |
| Target Name | MFN2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MFN2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1173-Ag-1 | Recombinant multi-species MFN2/ CMT2A/ CMT2A2 protein |
| ORF Viral Vector | pGMLV000716 | human MFN2 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000851 | human MFN2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000851 | human MFN2 Lentivirus particle |
| ORF Viral Vector | vGMLV000716 | human MFN2 Lentivirus particle |
| ORF Viral Vector | pGMLV000871 | human MFN2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000871 | human MFN2 Lentivirus particle |
| ORF Viral Vector | pGMLV000580 | Norway rat Mfn2 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000368 | rat Mfn2 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000479 | Norway rat Mfn2 Adenovirus plasmid |
| ORF Viral Vector | vGMLV000580 | Norway rat Mfn2 Lentivirus particle |
| ORF Viral Vector | vGMAD000368 | rat Mfn2 Adenovirus particle |
| ORF Viral Vector | vGMAD000479 | Norway rat Mfn2 Adenovirus particle |
Target information
| Target ID | GM-IP1173 |
| Target Name | MFN2 |
| Gene ID | 9927,170731,64476,100427191,487439,101101068,534574,100055966 |
| Gene Symbol and Synonyms | CMT2A,CMT2A2,CMT2A2A,CMT2A2B,CPRP1,D630023P19Rik,Fzo,HMSN6A,HSG,MARF,MFN2,MSL |
| Uniprot Accession | O95140,Q8R500 |
| Uniprot Entry Name | MFN2_HUMAN,MFN2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000116688 |
| Target Classification | N/A |
The target: MFN2, gene name: MFN2, also named as CMT2A, CMT2A2, CMT2A2A, CMT2A2B, CPRP1, HMSN6A, HSG, MARF. This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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