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Anti-MKKS monoclonal antibody
Pre-made anti-MKKS monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MKKS/MKKS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1195-Ab-1/ GM-Tg-hg-IP1195-Ab-2 | Anti-Human MKKS monoclonal antibody | Human |
| GM-Tg-rg-IP1195-Ab-1/ GM-Tg-rg-IP1195-Ab-2 | Anti-Rat MKKS monoclonal antibody | Rat |
| GM-Tg-mg-IP1195-Ab-1/ GM-Tg-mg-IP1195-Ab-2 | Anti-Mouse MKKS monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1195-Ab-1/ GM-Tg-cynog-IP1195-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MKKS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1195-Ab-1/ GM-Tg-felg-IP1195-Ab-2 | Anti-Feline MKKS monoclonal antibody | Feline |
| GM-Tg-cang-IP1195-Ab-1/ GM-Tg-cang-IP1195-Ab-2 | Anti-Canine MKKS monoclonal antibody | Canine |
| GM-Tg-bovg-IP1195-Ab-1/ GM-Tg-bovg-IP1195-Ab-2 | Anti-Bovine MKKS monoclonal antibody | Bovine |
| GM-Tg-equg-IP1195-Ab-1/ GM-Tg-equg-IP1195-Ab-2 | Anti-Equine MKKS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1195-Ab-1/ GM-Tg-hg-IP1195-Ab-2; GM-Tg-rg-IP1195-Ab-1/ GM-Tg-rg-IP1195-Ab-2; GM-Tg-mg-IP1195-Ab-1/ GM-Tg-mg-IP1195-Ab-2; GM-Tg-cynog-IP1195-Ab-1/ GM-Tg-cynog-IP1195-Ab-2; GM-Tg-felg-IP1195-Ab-1/ GM-Tg-felg-IP1195-Ab-2; GM-Tg-cang-IP1195-Ab-1/ GM-Tg-cang-IP1195-Ab-2; GM-Tg-bovg-IP1195-Ab-1/ GM-Tg-bovg-IP1195-Ab-2; GM-Tg-equg-IP1195-Ab-1/ GM-Tg-equg-IP1195-Ab-2 |
| Products Name | Anti-MKKS monoclonal antibody |
| Format | mab |
| Target Name | MKKS |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MKKS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1195-Ag-1 | Recombinant multi-species MKKS/ BBS6/ HMCS protein |
Target information
| Target ID | GM-IP1195 |
| Target Name | MKKS |
| Gene ID | 8195,59030,311456,718547,485771,101092927,614288,100064409 |
| Gene Symbol and Synonyms | 1300013E18Rik,BBS6,HMCS,KMS,MKKS,MKS |
| Uniprot Accession | Q9NPJ1 |
| Uniprot Entry Name | MKKS_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125863 |
| Target Classification | N/A |
The target: MKKS, gene name: MKKS, also named as BBS6, HMCS, KMS, MKS. This gene encodes a protein which shares sequence similarity with other members of the type II chaperonin family. The encoded protein is a centrosome-shuttling protein and plays an important role in cytokinesis. This protein also interacts with other type II chaperonin members to form a complex known as the BBSome, which involves ciliary membrane biogenesis. This protein is encoded by a downstream open reading frame (dORF). Several upstream open reading frames (uORFs) have been identified, which repress the translation of the dORF, and two of which can encode small mitochondrial membrane proteins. Mutations in this gene have been observed in patients with Bardet-Biedl syndrome type 6, also known as McKusick-Kaufman syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
