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Anti-MRVI1 monoclonal antibody
Pre-made anti-MRVI1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MRVI1/MRVI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1213-Ab-1/ GM-Tg-hg-IP1213-Ab-2 | Anti-Human MRVI1 monoclonal antibody | Human |
| GM-Tg-rg-IP1213-Ab-1/ GM-Tg-rg-IP1213-Ab-2 | Anti-Rat MRVI1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1213-Ab-1/ GM-Tg-mg-IP1213-Ab-2 | Anti-Mouse MRVI1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1213-Ab-1/ GM-Tg-cynog-IP1213-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MRVI1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1213-Ab-1/ GM-Tg-felg-IP1213-Ab-2 | Anti-Feline MRVI1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1213-Ab-1/ GM-Tg-cang-IP1213-Ab-2 | Anti-Canine MRVI1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1213-Ab-1/ GM-Tg-bovg-IP1213-Ab-2 | Anti-Bovine MRVI1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1213-Ab-1/ GM-Tg-equg-IP1213-Ab-2 | Anti-Equine MRVI1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1213-Ab-1/ GM-Tg-hg-IP1213-Ab-2; GM-Tg-rg-IP1213-Ab-1/ GM-Tg-rg-IP1213-Ab-2; GM-Tg-mg-IP1213-Ab-1/ GM-Tg-mg-IP1213-Ab-2; GM-Tg-cynog-IP1213-Ab-1/ GM-Tg-cynog-IP1213-Ab-2; GM-Tg-felg-IP1213-Ab-1/ GM-Tg-felg-IP1213-Ab-2; GM-Tg-cang-IP1213-Ab-1/ GM-Tg-cang-IP1213-Ab-2; GM-Tg-bovg-IP1213-Ab-1/ GM-Tg-bovg-IP1213-Ab-2; GM-Tg-equg-IP1213-Ab-1/ GM-Tg-equg-IP1213-Ab-2 |
| Products Name | Anti-MRVI1 monoclonal antibody |
| Format | mab |
| Target Name | MRVI1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MRVI1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1213-Ag-1 | Recombinant multi-species IRAG1/ MRVI1/ IRAG protein |
Target information
| Target ID | GM-IP1213 |
| Target Name | MRVI1 |
| Gene ID | 10335,17540,308899,702830,100855453,101088106,281918,100071324 |
| Gene Symbol and Synonyms | IRAG,IRAG1,JAW1L,MRVI1,Ris1 |
| Uniprot Accession | Q9Y6F6,Q9N1F0 |
| Uniprot Entry Name | IRAG1_HUMAN,IRAG1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000072952 |
| Target Classification | N/A |
The target: MRVI1, gene name: MRVI1, also named as IRAG, JAW1L. This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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