Anti-NCLN monoclonal antibody

Pre-made anti-NCLN monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to NCLN/NCLN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1242-Ab-1/ GM-Tg-hg-IP1242-Ab-2Anti-Human NCLN monoclonal antibodyHuman
GM-Tg-rg-IP1242-Ab-1/ GM-Tg-rg-IP1242-Ab-2Anti-Rat NCLN monoclonal antibodyRat
GM-Tg-mg-IP1242-Ab-1/ GM-Tg-mg-IP1242-Ab-2Anti-Mouse NCLN monoclonal antibodyMouse
GM-Tg-cynog-IP1242-Ab-1/ GM-Tg-cynog-IP1242-Ab-2Anti-Cynomolgus/ Rhesus macaque NCLN monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1242-Ab-1/ GM-Tg-felg-IP1242-Ab-2Anti-Feline NCLN monoclonal antibodyFeline
GM-Tg-cang-IP1242-Ab-1/ GM-Tg-cang-IP1242-Ab-2Anti-Canine NCLN monoclonal antibodyCanine
GM-Tg-bovg-IP1242-Ab-1/ GM-Tg-bovg-IP1242-Ab-2Anti-Bovine NCLN monoclonal antibodyBovine
GM-Tg-equg-IP1242-Ab-1/ GM-Tg-equg-IP1242-Ab-2Anti-Equine NCLN monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1242-Ab-1/ GM-Tg-hg-IP1242-Ab-2; GM-Tg-rg-IP1242-Ab-1/ GM-Tg-rg-IP1242-Ab-2;
GM-Tg-mg-IP1242-Ab-1/ GM-Tg-mg-IP1242-Ab-2; GM-Tg-cynog-IP1242-Ab-1/ GM-Tg-cynog-IP1242-Ab-2;
GM-Tg-felg-IP1242-Ab-1/ GM-Tg-felg-IP1242-Ab-2; GM-Tg-cang-IP1242-Ab-1/ GM-Tg-cang-IP1242-Ab-2;
GM-Tg-bovg-IP1242-Ab-1/ GM-Tg-bovg-IP1242-Ab-2; GM-Tg-equg-IP1242-Ab-1/ GM-Tg-equg-IP1242-Ab-2
Products NameAnti-NCLN monoclonal antibody
Formatmab
Target NameNCLN
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-NCLN monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1242-Ag-1Recombinant multi-species NCLN/ NET59 protein


    Target information

    Target IDGM-IP1242
    Target NameNCLN
    Gene ID56926,103425,314648,712703,485062,101087047,531802,100147568
    Gene Symbol and Synonyms3100002P13Rik,NCLN,NET59,RGD1309355
    Uniprot AccessionQ969V3,Q5XIA1
    Uniprot Entry NameNCLN_HUMAN,NCLN_RAT
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000125912
    Target ClassificationN/A

    The target: NCLN, gene name: NCLN, also named as NET59. Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.