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Anti-NDUFA1 monoclonal antibody
Pre-made anti-NDUFA1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NDUFA1/NDUFA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1252-Ab-1/ GM-Tg-hg-IP1252-Ab-2 | Anti-Human NDUFA1 monoclonal antibody | Human |
| GM-Tg-rg-IP1252-Ab-1/ GM-Tg-rg-IP1252-Ab-2 | Anti-Rat NDUFA1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1252-Ab-1/ GM-Tg-mg-IP1252-Ab-2 | Anti-Mouse NDUFA1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1252-Ab-1/ GM-Tg-cynog-IP1252-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NDUFA1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1252-Ab-1/ GM-Tg-felg-IP1252-Ab-2 | Anti-Feline NDUFA1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1252-Ab-1/ GM-Tg-cang-IP1252-Ab-2 | Anti-Canine NDUFA1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1252-Ab-1/ GM-Tg-bovg-IP1252-Ab-2 | Anti-Bovine NDUFA1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1252-Ab-1/ GM-Tg-equg-IP1252-Ab-2 | Anti-Equine NDUFA1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1252-Ab-1/ GM-Tg-hg-IP1252-Ab-2; GM-Tg-rg-IP1252-Ab-1/ GM-Tg-rg-IP1252-Ab-2; GM-Tg-mg-IP1252-Ab-1/ GM-Tg-mg-IP1252-Ab-2; GM-Tg-cynog-IP1252-Ab-1/ GM-Tg-cynog-IP1252-Ab-2; GM-Tg-felg-IP1252-Ab-1/ GM-Tg-felg-IP1252-Ab-2; GM-Tg-cang-IP1252-Ab-1/ GM-Tg-cang-IP1252-Ab-2; GM-Tg-bovg-IP1252-Ab-1/ GM-Tg-bovg-IP1252-Ab-2; GM-Tg-equg-IP1252-Ab-1/ GM-Tg-equg-IP1252-Ab-2 |
| Products Name | Anti-NDUFA1 monoclonal antibody |
| Format | mab |
| Target Name | NDUFA1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NDUFA1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1252-Ag-1 | Recombinant multi-species NDUA1/ NDUFA1/ CI-MWFE protein |
Target information
| Target ID | GM-IP1252 |
| Target Name | NDUFA1 |
| Gene ID | 4694,54405,363441,694635,102154035,101085609,327673,100058835 |
| Gene Symbol and Synonyms | 1810049F12Rik,CI-MWFE,MC1DN12,MWFE,NDUFA1,RGD1560955,ZNF183 |
| Uniprot Accession | O15239,Q02377 |
| Uniprot Entry Name | NDUA1_HUMAN,NDUA1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000125356 |
| Target Classification | N/A |
The target: NDUFA1, gene name: NDUFA1, also named as CI-MWFE, MWFE, ZNF183. The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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