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Anti-NUP188 monoclonal antibody
Pre-made anti-NUP188 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NUP188/NUP188 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1287-Ab-1/ GM-Tg-hg-IP1287-Ab-2 | Anti-Human NUP188 monoclonal antibody | Human |
| GM-Tg-rg-IP1287-Ab-1/ GM-Tg-rg-IP1287-Ab-2 | Anti-Rat NUP188 monoclonal antibody | Rat |
| GM-Tg-mg-IP1287-Ab-1/ GM-Tg-mg-IP1287-Ab-2 | Anti-Mouse NUP188 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1287-Ab-1/ GM-Tg-cynog-IP1287-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NUP188 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1287-Ab-1/ GM-Tg-felg-IP1287-Ab-2 | Anti-Feline NUP188 monoclonal antibody | Feline |
| GM-Tg-cang-IP1287-Ab-1/ GM-Tg-cang-IP1287-Ab-2 | Anti-Canine NUP188 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1287-Ab-1/ GM-Tg-bovg-IP1287-Ab-2 | Anti-Bovine NUP188 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1287-Ab-1/ GM-Tg-equg-IP1287-Ab-2 | Anti-Equine NUP188 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1287-Ab-1/ GM-Tg-hg-IP1287-Ab-2; GM-Tg-rg-IP1287-Ab-1/ GM-Tg-rg-IP1287-Ab-2; GM-Tg-mg-IP1287-Ab-1/ GM-Tg-mg-IP1287-Ab-2; GM-Tg-cynog-IP1287-Ab-1/ GM-Tg-cynog-IP1287-Ab-2; GM-Tg-felg-IP1287-Ab-1/ GM-Tg-felg-IP1287-Ab-2; GM-Tg-cang-IP1287-Ab-1/ GM-Tg-cang-IP1287-Ab-2; GM-Tg-bovg-IP1287-Ab-1/ GM-Tg-bovg-IP1287-Ab-2; GM-Tg-equg-IP1287-Ab-1/ GM-Tg-equg-IP1287-Ab-2 |
| Products Name | Anti-NUP188 monoclonal antibody |
| Format | mab |
| Target Name | NUP188 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NUP188 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1287-Ag-1 | Recombinant multi-species NU188/ NUP188/ KIAA0169 protein |
Target information
| Target ID | GM-IP1287 |
| Target Name | NUP188 |
| Gene ID | 23511,227699,366016,722580,491307,101094303,504307,100070114 |
| Gene Symbol and Synonyms | hNup188,KIAA0169,NUP188,SANDSTEF |
| Uniprot Accession | Q5SRE5 |
| Uniprot Entry Name | NU188_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000095319 |
| Target Classification | N/A |
The target: NUP188, gene name: NUP188, also named as KIAA0169, hNup188. The nuclear pore complex (NPC) is found on the nuclear envelope and forms a gateway that regulates the flow of proteins and RNAs between the cytoplasm and nucleoplasm. The NPC is comprised of approximately 30 distinct proteins collectively known as nucleoporins. Nucleoporins are pore-complex-specific glycoproteins which often have cytoplasmically oriented O-linked N-acetylglucosamine residues and numerous repeats of the pentapeptide sequence XFXFG. However, the nucleoporin protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. This nucleoporin is thought to form part of the scaffold for the central channel of the nuclear pore. [provided by RefSeq, Jan 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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