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Anti-PCDHGA5 monoclonal antibody
Pre-made anti-PCDHGA5 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PCDHGA5/PCDHGA5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1348-Ab-1/ GM-Tg-hg-IP1348-Ab-2 | Anti-Human PCDHGA5 monoclonal antibody | Human |
| GM-Tg-rg-IP1348-Ab-1/ GM-Tg-rg-IP1348-Ab-2 | Anti-Rat PCDHGA5 monoclonal antibody | Rat |
| GM-Tg-mg-IP1348-Ab-1/ GM-Tg-mg-IP1348-Ab-2 | Anti-Mouse PCDHGA5 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1348-Ab-1/ GM-Tg-cynog-IP1348-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PCDHGA5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1348-Ab-1/ GM-Tg-felg-IP1348-Ab-2 | Anti-Feline PCDHGA5 monoclonal antibody | Feline |
| GM-Tg-cang-IP1348-Ab-1/ GM-Tg-cang-IP1348-Ab-2 | Anti-Canine PCDHGA5 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1348-Ab-1/ GM-Tg-bovg-IP1348-Ab-2 | Anti-Bovine PCDHGA5 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1348-Ab-1/ GM-Tg-equg-IP1348-Ab-2 | Anti-Equine PCDHGA5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1348-Ab-1/ GM-Tg-hg-IP1348-Ab-2; GM-Tg-rg-IP1348-Ab-1/ GM-Tg-rg-IP1348-Ab-2; GM-Tg-mg-IP1348-Ab-1/ GM-Tg-mg-IP1348-Ab-2; GM-Tg-cynog-IP1348-Ab-1/ GM-Tg-cynog-IP1348-Ab-2; GM-Tg-felg-IP1348-Ab-1/ GM-Tg-felg-IP1348-Ab-2; GM-Tg-cang-IP1348-Ab-1/ GM-Tg-cang-IP1348-Ab-2; GM-Tg-bovg-IP1348-Ab-1/ GM-Tg-bovg-IP1348-Ab-2; GM-Tg-equg-IP1348-Ab-1/ GM-Tg-equg-IP1348-Ab-2 |
| Products Name | Anti-PCDHGA5 monoclonal antibody |
| Format | mab |
| Target Name | PCDHGA5 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PCDHGA5 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1348-Ag-1 | Recombinant multi-species PCDG5/ PCDHGA5/ CDH-GAMMA-A5 protein |
Target information
| Target ID | GM-IP1348 |
| Target Name | PCDHGA5 |
| Gene ID | 56110 |
| Gene Symbol and Synonyms | CDH-GAMMA-A5,ME3,PCDH-GAMMA-A5,PCDHGA5 |
| Uniprot Accession | Q9Y5G8 |
| Uniprot Entry Name | PCDG5_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000253485 |
| Target Classification | N/A |
The target: PCDHGA5, gene name: PCDHGA5, also named as CDH-GAMMA-A5, ME3, PCDH-GAMMA-A5. This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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