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Anti-PIAS2 monoclonal antibody
Pre-made anti-PIAS2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PIAS2/PIAS2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1385-Ab-1/ GM-Tg-hg-IP1385-Ab-2 | Anti-Human PIAS2 monoclonal antibody | Human |
| GM-Tg-rg-IP1385-Ab-1/ GM-Tg-rg-IP1385-Ab-2 | Anti-Rat PIAS2 monoclonal antibody | Rat |
| GM-Tg-mg-IP1385-Ab-1/ GM-Tg-mg-IP1385-Ab-2 | Anti-Mouse PIAS2 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1385-Ab-1/ GM-Tg-cynog-IP1385-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PIAS2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1385-Ab-1/ GM-Tg-felg-IP1385-Ab-2 | Anti-Feline PIAS2 monoclonal antibody | Feline |
| GM-Tg-cang-IP1385-Ab-1/ GM-Tg-cang-IP1385-Ab-2 | Anti-Canine PIAS2 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1385-Ab-1/ GM-Tg-bovg-IP1385-Ab-2 | Anti-Bovine PIAS2 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1385-Ab-1/ GM-Tg-equg-IP1385-Ab-2 | Anti-Equine PIAS2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1385-Ab-1/ GM-Tg-hg-IP1385-Ab-2; GM-Tg-rg-IP1385-Ab-1/ GM-Tg-rg-IP1385-Ab-2; GM-Tg-mg-IP1385-Ab-1/ GM-Tg-mg-IP1385-Ab-2; GM-Tg-cynog-IP1385-Ab-1/ GM-Tg-cynog-IP1385-Ab-2; GM-Tg-felg-IP1385-Ab-1/ GM-Tg-felg-IP1385-Ab-2; GM-Tg-cang-IP1385-Ab-1/ GM-Tg-cang-IP1385-Ab-2; GM-Tg-bovg-IP1385-Ab-1/ GM-Tg-bovg-IP1385-Ab-2; GM-Tg-equg-IP1385-Ab-1/ GM-Tg-equg-IP1385-Ab-2 |
| Products Name | Anti-PIAS2 monoclonal antibody |
| Format | mab |
| Target Name | PIAS2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PIAS2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1385-Ag-1 | Recombinant multi-species PIAS2/ ARIP3/ DIP protein |
| ORF Viral Vector | pGMLPm004281 | mouse Pias2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004281 | mouse Pias2 Lentivirus particle |
Target information
| Target ID | GM-IP1385 |
| Target Name | PIAS2 |
| Gene ID | 9063,17344,83422,696737,480147,101081835,533403,100068879 |
| Gene Symbol and Synonyms | ARIP3,Dib,DIP,MIZ1,PIAS2,PIASX,PIASxalpha,PIASxalpha6,PIASxb,PIASxbeta,SIZ2,ZMIZ4 |
| Uniprot Accession | O75928,Q6AZ28 |
| Uniprot Entry Name | PIAS2_HUMAN,PIAS2_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000078043 |
| Target Classification | N/A |
The target: PIAS2, gene name: PIAS2, also named as ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4. This gene encodes a member of the protein inhibitor of activated STAT family, which function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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