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Anti-PIGA monoclonal antibody
Pre-made anti-PIGA monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PIGA/PIGA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1386-Ab-1/ GM-Tg-hg-IP1386-Ab-2 | Anti-Human PIGA monoclonal antibody | Human |
| GM-Tg-rg-IP1386-Ab-1/ GM-Tg-rg-IP1386-Ab-2 | Anti-Rat PIGA monoclonal antibody | Rat |
| GM-Tg-mg-IP1386-Ab-1/ GM-Tg-mg-IP1386-Ab-2 | Anti-Mouse PIGA monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1386-Ab-1/ GM-Tg-cynog-IP1386-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PIGA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1386-Ab-1/ GM-Tg-felg-IP1386-Ab-2 | Anti-Feline PIGA monoclonal antibody | Feline |
| GM-Tg-cang-IP1386-Ab-1/ GM-Tg-cang-IP1386-Ab-2 | Anti-Canine PIGA monoclonal antibody | Canine |
| GM-Tg-bovg-IP1386-Ab-1/ GM-Tg-bovg-IP1386-Ab-2 | Anti-Bovine PIGA monoclonal antibody | Bovine |
| GM-Tg-equg-IP1386-Ab-1/ GM-Tg-equg-IP1386-Ab-2 | Anti-Equine PIGA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1386-Ab-1/ GM-Tg-hg-IP1386-Ab-2; GM-Tg-rg-IP1386-Ab-1/ GM-Tg-rg-IP1386-Ab-2; GM-Tg-mg-IP1386-Ab-1/ GM-Tg-mg-IP1386-Ab-2; GM-Tg-cynog-IP1386-Ab-1/ GM-Tg-cynog-IP1386-Ab-2; GM-Tg-felg-IP1386-Ab-1/ GM-Tg-felg-IP1386-Ab-2; GM-Tg-cang-IP1386-Ab-1/ GM-Tg-cang-IP1386-Ab-2; GM-Tg-bovg-IP1386-Ab-1/ GM-Tg-bovg-IP1386-Ab-2; GM-Tg-equg-IP1386-Ab-1/ GM-Tg-equg-IP1386-Ab-2 |
| Products Name | Anti-PIGA monoclonal antibody |
| Format | mab |
| Target Name | PIGA |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PIGA monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1386-Ag-1 | Recombinant multi-species PIGA/ GPI3/ MCAHS2 protein |
| ORF Viral Vector | vGMLP002934 | human PIGA Lentivirus particle |
| ORF Viral Vector | pGMLP002934 | human PIGA Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005295 | mouse Piga Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005295 | mouse Piga Lentivirus particle |
Target information
| Target ID | GM-IP1386 |
| Target Name | PIGA |
| Gene ID | 5277,18700,363464,712514,491748,101094735,100139601,100055827 |
| Gene Symbol and Synonyms | GPI3,MCAHS2,NEDEPH,PIG-A,PIGA,PNH1 |
| Uniprot Accession | P37287 |
| Uniprot Entry Name | PIGA_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000165195 |
| Target Classification | N/A |
The target: PIGA, gene name: PIGA, also named as GPI3, MCAHS2, PIG-A, PNH1. This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12. [provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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