Anti-POLR1E monoclonal antibody

Pre-made anti-POLR1E monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to POLR1E/POLR1E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1424-Ab-1/ GM-Tg-hg-IP1424-Ab-2Anti-Human POLR1E monoclonal antibodyHuman
GM-Tg-rg-IP1424-Ab-1/ GM-Tg-rg-IP1424-Ab-2Anti-Rat POLR1E monoclonal antibodyRat
GM-Tg-mg-IP1424-Ab-1/ GM-Tg-mg-IP1424-Ab-2Anti-Mouse POLR1E monoclonal antibodyMouse
GM-Tg-cynog-IP1424-Ab-1/ GM-Tg-cynog-IP1424-Ab-2Anti-Cynomolgus/ Rhesus macaque POLR1E monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1424-Ab-1/ GM-Tg-felg-IP1424-Ab-2Anti-Feline POLR1E monoclonal antibodyFeline
GM-Tg-cang-IP1424-Ab-1/ GM-Tg-cang-IP1424-Ab-2Anti-Canine POLR1E monoclonal antibodyCanine
GM-Tg-bovg-IP1424-Ab-1/ GM-Tg-bovg-IP1424-Ab-2Anti-Bovine POLR1E monoclonal antibodyBovine
GM-Tg-equg-IP1424-Ab-1/ GM-Tg-equg-IP1424-Ab-2Anti-Equine POLR1E monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1424-Ab-1/ GM-Tg-hg-IP1424-Ab-2; GM-Tg-rg-IP1424-Ab-1/ GM-Tg-rg-IP1424-Ab-2;
GM-Tg-mg-IP1424-Ab-1/ GM-Tg-mg-IP1424-Ab-2; GM-Tg-cynog-IP1424-Ab-1/ GM-Tg-cynog-IP1424-Ab-2;
GM-Tg-felg-IP1424-Ab-1/ GM-Tg-felg-IP1424-Ab-2; GM-Tg-cang-IP1424-Ab-1/ GM-Tg-cang-IP1424-Ab-2;
GM-Tg-bovg-IP1424-Ab-1/ GM-Tg-bovg-IP1424-Ab-2; GM-Tg-equg-IP1424-Ab-1/ GM-Tg-equg-IP1424-Ab-2
Products NameAnti-POLR1E monoclonal antibody
Formatmab
Target NamePOLR1E
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-POLR1E monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1424-Ag-1Recombinant multi-species RPA49/ POLR1E/ PAF53 protein


    Target information

    Target IDGM-IP1424
    Target NamePOLR1E
    Gene ID64425,64424,313245,716506,474767,101090299,511587,100066520
    Gene Symbol and Synonyms53kDa,A49,D030019D19Rik,PAF53,POLR1E,PRAF1,RGD1565773,RPA49
    Uniprot AccessionQ9GZS1
    Uniprot Entry NameRPA49_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000137054
    Target ClassificationN/A

    The target: POLR1E, gene name: POLR1E, also named as PAF53, PRAF1. Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and RNA polymerase I general transcription initiation factor binding activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.