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Anti-POMK monoclonal antibody
Pre-made anti-POMK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to POMK/POMK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1428-Ab-1/ GM-Tg-hg-IP1428-Ab-2 | Anti-Human POMK monoclonal antibody | Human |
| GM-Tg-rg-IP1428-Ab-1/ GM-Tg-rg-IP1428-Ab-2 | Anti-Rat POMK monoclonal antibody | Rat |
| GM-Tg-mg-IP1428-Ab-1/ GM-Tg-mg-IP1428-Ab-2 | Anti-Mouse POMK monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1428-Ab-1/ GM-Tg-cynog-IP1428-Ab-2 | Anti-Cynomolgus/ Rhesus macaque POMK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1428-Ab-1/ GM-Tg-felg-IP1428-Ab-2 | Anti-Feline POMK monoclonal antibody | Feline |
| GM-Tg-cang-IP1428-Ab-1/ GM-Tg-cang-IP1428-Ab-2 | Anti-Canine POMK monoclonal antibody | Canine |
| GM-Tg-bovg-IP1428-Ab-1/ GM-Tg-bovg-IP1428-Ab-2 | Anti-Bovine POMK monoclonal antibody | Bovine |
| GM-Tg-equg-IP1428-Ab-1/ GM-Tg-equg-IP1428-Ab-2 | Anti-Equine POMK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1428-Ab-1/ GM-Tg-hg-IP1428-Ab-2; GM-Tg-rg-IP1428-Ab-1/ GM-Tg-rg-IP1428-Ab-2; GM-Tg-mg-IP1428-Ab-1/ GM-Tg-mg-IP1428-Ab-2; GM-Tg-cynog-IP1428-Ab-1/ GM-Tg-cynog-IP1428-Ab-2; GM-Tg-felg-IP1428-Ab-1/ GM-Tg-felg-IP1428-Ab-2; GM-Tg-cang-IP1428-Ab-1/ GM-Tg-cang-IP1428-Ab-2; GM-Tg-bovg-IP1428-Ab-1/ GM-Tg-bovg-IP1428-Ab-2; GM-Tg-equg-IP1428-Ab-1/ GM-Tg-equg-IP1428-Ab-2 |
| Products Name | Anti-POMK monoclonal antibody |
| Format | mab |
| Target Name | POMK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-POMK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1428-Ag-1 | Recombinant multi-species SG196/ POMK/ MDDGA12 protein |
Target information
| Target ID | GM-IP1428 |
| Target Name | POMK |
| Gene ID | 84197,74653,306549,706318,482834,102902090,514490,100053457 |
| Gene Symbol and Synonyms | 4930444A02Rik,MDDGA12,MDDGC12,POMK,RGD1310810,SGK196 |
| Uniprot Accession | Q9H5K3,Q4V8A9 |
| Uniprot Entry Name | SG196_HUMAN,SG196_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000185900 |
| Target Classification | Kinase |
The target: POMK, gene name: POMK, also named as MDDGA12, MDDGC12, SGK196. This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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