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Anti-PPM1L monoclonal antibody
Pre-made anti-PPM1L monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PPM1L/PPM1L products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1436-Ab-1/ GM-Tg-hg-IP1436-Ab-2 | Anti-Human PPM1L monoclonal antibody | Human |
| GM-Tg-rg-IP1436-Ab-1/ GM-Tg-rg-IP1436-Ab-2 | Anti-Rat PPM1L monoclonal antibody | Rat |
| GM-Tg-mg-IP1436-Ab-1/ GM-Tg-mg-IP1436-Ab-2 | Anti-Mouse PPM1L monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1436-Ab-1/ GM-Tg-cynog-IP1436-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PPM1L monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1436-Ab-1/ GM-Tg-felg-IP1436-Ab-2 | Anti-Feline PPM1L monoclonal antibody | Feline |
| GM-Tg-cang-IP1436-Ab-1/ GM-Tg-cang-IP1436-Ab-2 | Anti-Canine PPM1L monoclonal antibody | Canine |
| GM-Tg-bovg-IP1436-Ab-1/ GM-Tg-bovg-IP1436-Ab-2 | Anti-Bovine PPM1L monoclonal antibody | Bovine |
| GM-Tg-equg-IP1436-Ab-1/ GM-Tg-equg-IP1436-Ab-2 | Anti-Equine PPM1L monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1436-Ab-1/ GM-Tg-hg-IP1436-Ab-2; GM-Tg-rg-IP1436-Ab-1/ GM-Tg-rg-IP1436-Ab-2; GM-Tg-mg-IP1436-Ab-1/ GM-Tg-mg-IP1436-Ab-2; GM-Tg-cynog-IP1436-Ab-1/ GM-Tg-cynog-IP1436-Ab-2; GM-Tg-felg-IP1436-Ab-1/ GM-Tg-felg-IP1436-Ab-2; GM-Tg-cang-IP1436-Ab-1/ GM-Tg-cang-IP1436-Ab-2; GM-Tg-bovg-IP1436-Ab-1/ GM-Tg-bovg-IP1436-Ab-2; GM-Tg-equg-IP1436-Ab-1/ GM-Tg-equg-IP1436-Ab-2 |
| Products Name | Anti-PPM1L monoclonal antibody |
| Format | mab |
| Target Name | PPM1L |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PPM1L monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1436-Ag-1 | Recombinant multi-species PPM1L/ PP2C-epsilon/ PP2CE protein |
| ORF Viral Vector | pGMLPm003270 | mouse Ppm1l Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003270 | mouse Ppm1l Lentivirus particle |
Target information
| Target ID | GM-IP1436 |
| Target Name | PPM1L |
| Gene ID | 151742,242083,310506,702049,608708,101092959,541235,100061927 |
| Gene Symbol and Synonyms | 3222401G13,5930404J21Rik,mKIAA4175,PP2C,PP2C-epsilon,PP2CE,PP2Cepsilon,PPM1-LIKE,PPM1L,Ppp2ce |
| Uniprot Accession | Q5SGD2,A5PJZ2 |
| Uniprot Entry Name | PPM1L_HUMAN,PPM1L_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000163590 |
| Target Classification | N/A |
The target: PPM1L, gene name: PPM1L, also named as PP2C-epsilon, PP2CE, PPM1-LIKE. The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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