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Anti-RBL1 monoclonal antibody
Pre-made anti-RBL1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RBL1/RBL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1473-Ab-1/ GM-Tg-hg-IP1473-Ab-2 | Anti-Human RBL1 monoclonal antibody | Human |
| GM-Tg-rg-IP1473-Ab-1/ GM-Tg-rg-IP1473-Ab-2 | Anti-Rat RBL1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1473-Ab-1/ GM-Tg-mg-IP1473-Ab-2 | Anti-Mouse RBL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1473-Ab-1/ GM-Tg-cynog-IP1473-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RBL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1473-Ab-1/ GM-Tg-felg-IP1473-Ab-2 | Anti-Feline RBL1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1473-Ab-1/ GM-Tg-cang-IP1473-Ab-2 | Anti-Canine RBL1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1473-Ab-1/ GM-Tg-bovg-IP1473-Ab-2 | Anti-Bovine RBL1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1473-Ab-1/ GM-Tg-equg-IP1473-Ab-2 | Anti-Equine RBL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1473-Ab-1/ GM-Tg-hg-IP1473-Ab-2; GM-Tg-rg-IP1473-Ab-1/ GM-Tg-rg-IP1473-Ab-2; GM-Tg-mg-IP1473-Ab-1/ GM-Tg-mg-IP1473-Ab-2; GM-Tg-cynog-IP1473-Ab-1/ GM-Tg-cynog-IP1473-Ab-2; GM-Tg-felg-IP1473-Ab-1/ GM-Tg-felg-IP1473-Ab-2; GM-Tg-cang-IP1473-Ab-1/ GM-Tg-cang-IP1473-Ab-2; GM-Tg-bovg-IP1473-Ab-1/ GM-Tg-bovg-IP1473-Ab-2; GM-Tg-equg-IP1473-Ab-1/ GM-Tg-equg-IP1473-Ab-2 |
| Products Name | Anti-RBL1 monoclonal antibody |
| Format | mab |
| Target Name | RBL1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RBL1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1473-Ag-1 | Recombinant multi-species RBL1/ CP107/ PRB1 protein |
Target information
| Target ID | GM-IP1473 |
| Target Name | RBL1 |
| Gene ID | 5933,19650,680111,701650,477221,101095164,524870,100069786 |
| Gene Symbol and Synonyms | CP107,p107,PRB1,RBL1 |
| Uniprot Accession | P28749,D3ZS28 |
| Uniprot Entry Name | RBL1_HUMAN,RBL1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000080839 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RBL1, gene name: RBL1, also named as CP107, PRB1, p107. The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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