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Anti-RNF103 monoclonal antibody
Pre-made anti-RNF103 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RNF103/RNF103 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1500-Ab-1/ GM-Tg-hg-IP1500-Ab-2 | Anti-Human RNF103 monoclonal antibody | Human |
| GM-Tg-rg-IP1500-Ab-1/ GM-Tg-rg-IP1500-Ab-2 | Anti-Rat RNF103 monoclonal antibody | Rat |
| GM-Tg-mg-IP1500-Ab-1/ GM-Tg-mg-IP1500-Ab-2 | Anti-Mouse RNF103 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1500-Ab-1/ GM-Tg-cynog-IP1500-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RNF103 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1500-Ab-1/ GM-Tg-felg-IP1500-Ab-2 | Anti-Feline RNF103 monoclonal antibody | Feline |
| GM-Tg-cang-IP1500-Ab-1/ GM-Tg-cang-IP1500-Ab-2 | Anti-Canine RNF103 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1500-Ab-1/ GM-Tg-bovg-IP1500-Ab-2 | Anti-Bovine RNF103 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1500-Ab-1/ GM-Tg-equg-IP1500-Ab-2 | Anti-Equine RNF103 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1500-Ab-1/ GM-Tg-hg-IP1500-Ab-2; GM-Tg-rg-IP1500-Ab-1/ GM-Tg-rg-IP1500-Ab-2; GM-Tg-mg-IP1500-Ab-1/ GM-Tg-mg-IP1500-Ab-2; GM-Tg-cynog-IP1500-Ab-1/ GM-Tg-cynog-IP1500-Ab-2; GM-Tg-felg-IP1500-Ab-1/ GM-Tg-felg-IP1500-Ab-2; GM-Tg-cang-IP1500-Ab-1/ GM-Tg-cang-IP1500-Ab-2; GM-Tg-bovg-IP1500-Ab-1/ GM-Tg-bovg-IP1500-Ab-2; GM-Tg-equg-IP1500-Ab-1/ GM-Tg-equg-IP1500-Ab-2 |
| Products Name | Anti-RNF103 monoclonal antibody |
| Format | mab |
| Target Name | RNF103 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RNF103 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1500-Ag-1 | Recombinant multi-species RN103/ RNF103/ HKF-1 protein |
Target information
| Target ID | GM-IP1500 |
| Target Name | RNF103 |
| Gene ID | 7844,22644,84508,511639,100052907 |
| Gene Symbol and Synonyms | Adrg34,HKF-1,KF-1,KF1,RNF103,ZFP-103,ZFP103 |
| Uniprot Accession | O00237,Q9EPZ8 |
| Uniprot Entry Name | RN103_HUMAN,RN103_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000239305 |
| Target Classification | N/A |
The target: RNF103, gene name: RNF103, also named as HKF-1, KF-1, KF1, ZFP-103, ZFP103. The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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