Anti-RNF183 monoclonal antibody

Pre-made anti-RNF183 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to RNF183/RNF183 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1519-Ab-1/ GM-Tg-hg-IP1519-Ab-2Anti-Human RNF183 monoclonal antibodyHuman
GM-Tg-rg-IP1519-Ab-1/ GM-Tg-rg-IP1519-Ab-2Anti-Rat RNF183 monoclonal antibodyRat
GM-Tg-mg-IP1519-Ab-1/ GM-Tg-mg-IP1519-Ab-2Anti-Mouse RNF183 monoclonal antibodyMouse
GM-Tg-cynog-IP1519-Ab-1/ GM-Tg-cynog-IP1519-Ab-2Anti-Cynomolgus/ Rhesus macaque RNF183 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1519-Ab-1/ GM-Tg-felg-IP1519-Ab-2Anti-Feline RNF183 monoclonal antibodyFeline
GM-Tg-cang-IP1519-Ab-1/ GM-Tg-cang-IP1519-Ab-2Anti-Canine RNF183 monoclonal antibodyCanine
GM-Tg-bovg-IP1519-Ab-1/ GM-Tg-bovg-IP1519-Ab-2Anti-Bovine RNF183 monoclonal antibodyBovine
GM-Tg-equg-IP1519-Ab-1/ GM-Tg-equg-IP1519-Ab-2Anti-Equine RNF183 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1519-Ab-1/ GM-Tg-hg-IP1519-Ab-2; GM-Tg-rg-IP1519-Ab-1/ GM-Tg-rg-IP1519-Ab-2;
GM-Tg-mg-IP1519-Ab-1/ GM-Tg-mg-IP1519-Ab-2; GM-Tg-cynog-IP1519-Ab-1/ GM-Tg-cynog-IP1519-Ab-2;
GM-Tg-felg-IP1519-Ab-1/ GM-Tg-felg-IP1519-Ab-2; GM-Tg-cang-IP1519-Ab-1/ GM-Tg-cang-IP1519-Ab-2;
GM-Tg-bovg-IP1519-Ab-1/ GM-Tg-bovg-IP1519-Ab-2; GM-Tg-equg-IP1519-Ab-1/ GM-Tg-equg-IP1519-Ab-2
Products NameAnti-RNF183 monoclonal antibody
Formatmab
Target NameRNF183
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-RNF183 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1519-Ag-1Recombinant multi-species RN183/ RNF183 protein


    Target information

    Target IDGM-IP1519
    Target NameRNF183
    Gene ID138065,76072,500474,705679,100684892,101096179,539200,100050237
    Gene Symbol and Synonyms5830442J12Rik,RGD1564412,RNF183
    Uniprot AccessionQ96D59,Q3SWY0
    Uniprot Entry NameRN183_HUMAN,RN183_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000165188
    Target ClassificationN/A

    The target: RNF183, gene name: RNF183, also named as . Enables ubiquitin protein ligase activity. Involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; protein ubiquitination; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.