- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-RNF217 monoclonal antibody
Pre-made anti-RNF217 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RNF217/RNF217 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1526-Ab-1/ GM-Tg-hg-IP1526-Ab-2 | Anti-Human RNF217 monoclonal antibody | Human |
| GM-Tg-rg-IP1526-Ab-1/ GM-Tg-rg-IP1526-Ab-2 | Anti-Rat RNF217 monoclonal antibody | Rat |
| GM-Tg-mg-IP1526-Ab-1/ GM-Tg-mg-IP1526-Ab-2 | Anti-Mouse RNF217 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1526-Ab-1/ GM-Tg-cynog-IP1526-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RNF217 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1526-Ab-1/ GM-Tg-felg-IP1526-Ab-2 | Anti-Feline RNF217 monoclonal antibody | Feline |
| GM-Tg-cang-IP1526-Ab-1/ GM-Tg-cang-IP1526-Ab-2 | Anti-Canine RNF217 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1526-Ab-1/ GM-Tg-bovg-IP1526-Ab-2 | Anti-Bovine RNF217 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1526-Ab-1/ GM-Tg-equg-IP1526-Ab-2 | Anti-Equine RNF217 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1526-Ab-1/ GM-Tg-hg-IP1526-Ab-2; GM-Tg-rg-IP1526-Ab-1/ GM-Tg-rg-IP1526-Ab-2; GM-Tg-mg-IP1526-Ab-1/ GM-Tg-mg-IP1526-Ab-2; GM-Tg-cynog-IP1526-Ab-1/ GM-Tg-cynog-IP1526-Ab-2; GM-Tg-felg-IP1526-Ab-1/ GM-Tg-felg-IP1526-Ab-2; GM-Tg-cang-IP1526-Ab-1/ GM-Tg-cang-IP1526-Ab-2; GM-Tg-bovg-IP1526-Ab-1/ GM-Tg-bovg-IP1526-Ab-2; GM-Tg-equg-IP1526-Ab-1/ GM-Tg-equg-IP1526-Ab-2 |
| Products Name | Anti-RNF217 monoclonal antibody |
| Format | mab |
| Target Name | RNF217 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RNF217 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1526-Ag-1 | Recombinant multi-species RN217/ RNF217/ C6orf172 protein |
Target information
| Target ID | GM-IP1526 |
| Target Name | RNF217 |
| Gene ID | 154214,268291,292188,716647,484112,101081895,541287,100073006 |
| Gene Symbol and Synonyms | C6orf172,dJ84N20.1,IBRDC1,OSTL,RNF217 |
| Uniprot Accession | Q8TC41 |
| Uniprot Entry Name | RN217_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000146373 |
| Target Classification | N/A |
The target: RNF217, gene name: RNF217, also named as C6orf172, IBRDC1, OSTL, dJ84N20.1. This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
