Anti-RRM2B monoclonal antibody

Pre-made anti-RRM2B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to RRM2B/RRM2B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1559-Ab-1/ GM-Tg-hg-IP1559-Ab-2Anti-Human RRM2B monoclonal antibodyHuman
GM-Tg-rg-IP1559-Ab-1/ GM-Tg-rg-IP1559-Ab-2Anti-Rat RRM2B monoclonal antibodyRat
GM-Tg-mg-IP1559-Ab-1/ GM-Tg-mg-IP1559-Ab-2Anti-Mouse RRM2B monoclonal antibodyMouse
GM-Tg-cynog-IP1559-Ab-1/ GM-Tg-cynog-IP1559-Ab-2Anti-Cynomolgus/ Rhesus macaque RRM2B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1559-Ab-1/ GM-Tg-felg-IP1559-Ab-2Anti-Feline RRM2B monoclonal antibodyFeline
GM-Tg-cang-IP1559-Ab-1/ GM-Tg-cang-IP1559-Ab-2Anti-Canine RRM2B monoclonal antibodyCanine
GM-Tg-bovg-IP1559-Ab-1/ GM-Tg-bovg-IP1559-Ab-2Anti-Bovine RRM2B monoclonal antibodyBovine
GM-Tg-equg-IP1559-Ab-1/ GM-Tg-equg-IP1559-Ab-2Anti-Equine RRM2B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1559-Ab-1/ GM-Tg-hg-IP1559-Ab-2; GM-Tg-rg-IP1559-Ab-1/ GM-Tg-rg-IP1559-Ab-2;
GM-Tg-mg-IP1559-Ab-1/ GM-Tg-mg-IP1559-Ab-2; GM-Tg-cynog-IP1559-Ab-1/ GM-Tg-cynog-IP1559-Ab-2;
GM-Tg-felg-IP1559-Ab-1/ GM-Tg-felg-IP1559-Ab-2; GM-Tg-cang-IP1559-Ab-1/ GM-Tg-cang-IP1559-Ab-2;
GM-Tg-bovg-IP1559-Ab-1/ GM-Tg-bovg-IP1559-Ab-2; GM-Tg-equg-IP1559-Ab-1/ GM-Tg-equg-IP1559-Ab-2
Products NameAnti-RRM2B monoclonal antibody
Formatmab
Target NameRRM2B
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-RRM2B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1559-Ag-1Recombinant multi-species RIR2B/ RRM2B/ MTDPS8A protein


    Target information

    Target IDGM-IP1559
    Target NameRRM2B
    Gene ID50484,382985,299976,707062,481988,101099777,528960,100062030
    Gene Symbol and SynonymsMTDPS8A,MTDPS8B,P53R2,RCDFRD,RRM2B
    Uniprot AccessionQ7LG56
    Uniprot Entry NameRIR2B_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000048392
    Target ClassificationN/A

    The target: RRM2B, gene name: RRM2B, also named as MTDPS8A, MTDPS8B, P53R2. This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.