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Anti-SCN7A monoclonal antibody
Pre-made anti-SCN7A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SCN7A/SCN7A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1587-Ab-1/ GM-Tg-hg-IP1587-Ab-2 | Anti-Human SCN7A monoclonal antibody | Human |
| GM-Tg-rg-IP1587-Ab-1/ GM-Tg-rg-IP1587-Ab-2 | Anti-Rat SCN7A monoclonal antibody | Rat |
| GM-Tg-mg-IP1587-Ab-1/ GM-Tg-mg-IP1587-Ab-2 | Anti-Mouse SCN7A monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1587-Ab-1/ GM-Tg-cynog-IP1587-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SCN7A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1587-Ab-1/ GM-Tg-felg-IP1587-Ab-2 | Anti-Feline SCN7A monoclonal antibody | Feline |
| GM-Tg-cang-IP1587-Ab-1/ GM-Tg-cang-IP1587-Ab-2 | Anti-Canine SCN7A monoclonal antibody | Canine |
| GM-Tg-bovg-IP1587-Ab-1/ GM-Tg-bovg-IP1587-Ab-2 | Anti-Bovine SCN7A monoclonal antibody | Bovine |
| GM-Tg-equg-IP1587-Ab-1/ GM-Tg-equg-IP1587-Ab-2 | Anti-Equine SCN7A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1587-Ab-1/ GM-Tg-hg-IP1587-Ab-2; GM-Tg-rg-IP1587-Ab-1/ GM-Tg-rg-IP1587-Ab-2; GM-Tg-mg-IP1587-Ab-1/ GM-Tg-mg-IP1587-Ab-2; GM-Tg-cynog-IP1587-Ab-1/ GM-Tg-cynog-IP1587-Ab-2; GM-Tg-felg-IP1587-Ab-1/ GM-Tg-felg-IP1587-Ab-2; GM-Tg-cang-IP1587-Ab-1/ GM-Tg-cang-IP1587-Ab-2; GM-Tg-bovg-IP1587-Ab-1/ GM-Tg-bovg-IP1587-Ab-2; GM-Tg-equg-IP1587-Ab-1/ GM-Tg-equg-IP1587-Ab-2 |
| Products Name | Anti-SCN7A monoclonal antibody |
| Format | mab |
| Target Name | SCN7A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SCN7A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1587-Ag-1 | Recombinant multi-species SCN7A/ NaG/ Nav2.1 protein |
Target information
| Target ID | GM-IP1587 |
| Target Name | SCN7A |
| Gene ID | 6332,20272,64155,704414,488382,101082080,507516,100062186 |
| Gene Symbol and Synonyms | 1110034K09Rik,Na-G,NaG,Nav2,Nav2.1,Nav2.2,Nav2.3,Nax,SCN6A,SCN7A |
| Uniprot Accession | Q01118 |
| Uniprot Entry Name | SCN7A_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000136546 |
| Target Classification | Ion Channel |
The target: SCN7A, gene name: SCN7A, also named as NaG, Nav2.1, Nav2.2, SCN6A. This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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