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Anti-SDHC monoclonal antibody
Pre-made anti-SDHC monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SDHC/SDHC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1588-Ab-1/ GM-Tg-hg-IP1588-Ab-2 | Anti-Human SDHC monoclonal antibody | Human |
| GM-Tg-rg-IP1588-Ab-1/ GM-Tg-rg-IP1588-Ab-2 | Anti-Rat SDHC monoclonal antibody | Rat |
| GM-Tg-mg-IP1588-Ab-1/ GM-Tg-mg-IP1588-Ab-2 | Anti-Mouse SDHC monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1588-Ab-1/ GM-Tg-cynog-IP1588-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SDHC monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1588-Ab-1/ GM-Tg-felg-IP1588-Ab-2 | Anti-Feline SDHC monoclonal antibody | Feline |
| GM-Tg-cang-IP1588-Ab-1/ GM-Tg-cang-IP1588-Ab-2 | Anti-Canine SDHC monoclonal antibody | Canine |
| GM-Tg-bovg-IP1588-Ab-1/ GM-Tg-bovg-IP1588-Ab-2 | Anti-Bovine SDHC monoclonal antibody | Bovine |
| GM-Tg-equg-IP1588-Ab-1/ GM-Tg-equg-IP1588-Ab-2 | Anti-Equine SDHC monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1588-Ab-1/ GM-Tg-hg-IP1588-Ab-2; GM-Tg-rg-IP1588-Ab-1/ GM-Tg-rg-IP1588-Ab-2; GM-Tg-mg-IP1588-Ab-1/ GM-Tg-mg-IP1588-Ab-2; GM-Tg-cynog-IP1588-Ab-1/ GM-Tg-cynog-IP1588-Ab-2; GM-Tg-felg-IP1588-Ab-1/ GM-Tg-felg-IP1588-Ab-2; GM-Tg-cang-IP1588-Ab-1/ GM-Tg-cang-IP1588-Ab-2; GM-Tg-bovg-IP1588-Ab-1/ GM-Tg-bovg-IP1588-Ab-2; GM-Tg-equg-IP1588-Ab-1/ GM-Tg-equg-IP1588-Ab-2 |
| Products Name | Anti-SDHC monoclonal antibody |
| Format | mab |
| Target Name | SDHC |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SDHC monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1588-Ag-1 | Recombinant multi-species C560/ SDHC/ CYB560 protein |
| ORF Viral Vector | vGMLP002909 | human SDHC Lentivirus particle |
| ORF Viral Vector | pGMLP002909 | human SDHC Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000851 | mouse Sdhc Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000851 | mouse Sdhc Lentivirus particle |
Target information
| Target ID | GM-IP1588 |
| Target Name | SDHC |
| Gene ID | 6391,66052,289217,719978,478983,101087808,327696,100065940 |
| Gene Symbol and Synonyms | 0610010E03Rik,CYB560,CYBL,PGL3,QPS1,SDH3,SDHC |
| Uniprot Accession | Q99643,P35720 |
| Uniprot Entry Name | C560_HUMAN,C560_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000143252 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SDHC, gene name: SDHC, also named as CYB560, CYBL, PGL3, QPS1, SDH3. This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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