Anti-SMG8 monoclonal antibody

Pre-made anti-SMG8 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to SMG8/SMG8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP1759-Ab-1/ GM-Tg-hg-IP1759-Ab-2Anti-Human SMG8 monoclonal antibodyHuman
GM-Tg-rg-IP1759-Ab-1/ GM-Tg-rg-IP1759-Ab-2Anti-Rat SMG8 monoclonal antibodyRat
GM-Tg-mg-IP1759-Ab-1/ GM-Tg-mg-IP1759-Ab-2Anti-Mouse SMG8 monoclonal antibodyMouse
GM-Tg-cynog-IP1759-Ab-1/ GM-Tg-cynog-IP1759-Ab-2Anti-Cynomolgus/ Rhesus macaque SMG8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP1759-Ab-1/ GM-Tg-felg-IP1759-Ab-2Anti-Feline SMG8 monoclonal antibodyFeline
GM-Tg-cang-IP1759-Ab-1/ GM-Tg-cang-IP1759-Ab-2Anti-Canine SMG8 monoclonal antibodyCanine
GM-Tg-bovg-IP1759-Ab-1/ GM-Tg-bovg-IP1759-Ab-2Anti-Bovine SMG8 monoclonal antibodyBovine
GM-Tg-equg-IP1759-Ab-1/ GM-Tg-equg-IP1759-Ab-2Anti-Equine SMG8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP1759-Ab-1/ GM-Tg-hg-IP1759-Ab-2; GM-Tg-rg-IP1759-Ab-1/ GM-Tg-rg-IP1759-Ab-2;
GM-Tg-mg-IP1759-Ab-1/ GM-Tg-mg-IP1759-Ab-2; GM-Tg-cynog-IP1759-Ab-1/ GM-Tg-cynog-IP1759-Ab-2;
GM-Tg-felg-IP1759-Ab-1/ GM-Tg-felg-IP1759-Ab-2; GM-Tg-cang-IP1759-Ab-1/ GM-Tg-cang-IP1759-Ab-2;
GM-Tg-bovg-IP1759-Ab-1/ GM-Tg-bovg-IP1759-Ab-2; GM-Tg-equg-IP1759-Ab-1/ GM-Tg-equg-IP1759-Ab-2
Products NameAnti-SMG8 monoclonal antibody
Formatmab
Target NameSMG8
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-SMG8 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP1759-Ag-1Recombinant multi-species SMG8/ C17orf71 protein


    Target information

    Target IDGM-IP1759
    Target NameSMG8
    Gene ID55181,74133,287596,711172,491116,101094638,522040,100057203
    Gene Symbol and Synonyms1200011M11Rik,ALKUS,C17orf71,C19H17orf71,RGD1306862,SMG8
    Uniprot AccessionQ8ND04,A1A4J7
    Uniprot Entry NameSMG8_HUMAN,SMG8_BOVIN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000167447
    Target ClassificationN/A

    The target: SMG8, gene name: SMG8, also named as C17orf71. Involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.