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Anti-SPAG4 monoclonal antibody
Pre-made anti-SPAG4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SPAG4/SPAG4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1791-Ab-1/ GM-Tg-hg-IP1791-Ab-2 | Anti-Human SPAG4 monoclonal antibody | Human |
| GM-Tg-rg-IP1791-Ab-1/ GM-Tg-rg-IP1791-Ab-2 | Anti-Rat SPAG4 monoclonal antibody | Rat |
| GM-Tg-mg-IP1791-Ab-1/ GM-Tg-mg-IP1791-Ab-2 | Anti-Mouse SPAG4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1791-Ab-1/ GM-Tg-cynog-IP1791-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPAG4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1791-Ab-1/ GM-Tg-felg-IP1791-Ab-2 | Anti-Feline SPAG4 monoclonal antibody | Feline |
| GM-Tg-cang-IP1791-Ab-1/ GM-Tg-cang-IP1791-Ab-2 | Anti-Canine SPAG4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1791-Ab-1/ GM-Tg-bovg-IP1791-Ab-2 | Anti-Bovine SPAG4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1791-Ab-1/ GM-Tg-equg-IP1791-Ab-2 | Anti-Equine SPAG4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1791-Ab-1/ GM-Tg-hg-IP1791-Ab-2; GM-Tg-rg-IP1791-Ab-1/ GM-Tg-rg-IP1791-Ab-2; GM-Tg-mg-IP1791-Ab-1/ GM-Tg-mg-IP1791-Ab-2; GM-Tg-cynog-IP1791-Ab-1/ GM-Tg-cynog-IP1791-Ab-2; GM-Tg-felg-IP1791-Ab-1/ GM-Tg-felg-IP1791-Ab-2; GM-Tg-cang-IP1791-Ab-1/ GM-Tg-cang-IP1791-Ab-2; GM-Tg-bovg-IP1791-Ab-1/ GM-Tg-bovg-IP1791-Ab-2; GM-Tg-equg-IP1791-Ab-1/ GM-Tg-equg-IP1791-Ab-2 |
| Products Name | Anti-SPAG4 monoclonal antibody |
| Format | mab |
| Target Name | SPAG4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SPAG4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1791-Ag-1 | Recombinant multi-species SPAG4/ CT127/ SUN4 protein |
Target information
| Target ID | GM-IP1791 |
| Target Name | SPAG4 |
| Gene ID | 6676,245865,83623,704522,485854,101080446,618468,100147206 |
| Gene Symbol and Synonyms | 1700041K21Rik,CT127,mKIAA4118,MNCb-0953,SPAG4,SUN4 |
| Uniprot Accession | Q9NPE6,O55034 |
| Uniprot Entry Name | SPAG4_HUMAN,SPAG4_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000061656 |
| Target Classification | N/A |
The target: SPAG4, gene name: SPAG4, also named as CT127, SUN4. The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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