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Anti-SPAST monoclonal antibody
Pre-made anti-SPAST monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SPAST/SPAST products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1794-Ab-1/ GM-Tg-hg-IP1794-Ab-2 | Anti-Human SPAST monoclonal antibody | Human |
| GM-Tg-rg-IP1794-Ab-1/ GM-Tg-rg-IP1794-Ab-2 | Anti-Rat SPAST monoclonal antibody | Rat |
| GM-Tg-mg-IP1794-Ab-1/ GM-Tg-mg-IP1794-Ab-2 | Anti-Mouse SPAST monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1794-Ab-1/ GM-Tg-cynog-IP1794-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPAST monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1794-Ab-1/ GM-Tg-felg-IP1794-Ab-2 | Anti-Feline SPAST monoclonal antibody | Feline |
| GM-Tg-cang-IP1794-Ab-1/ GM-Tg-cang-IP1794-Ab-2 | Anti-Canine SPAST monoclonal antibody | Canine |
| GM-Tg-bovg-IP1794-Ab-1/ GM-Tg-bovg-IP1794-Ab-2 | Anti-Bovine SPAST monoclonal antibody | Bovine |
| GM-Tg-equg-IP1794-Ab-1/ GM-Tg-equg-IP1794-Ab-2 | Anti-Equine SPAST monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1794-Ab-1/ GM-Tg-hg-IP1794-Ab-2; GM-Tg-rg-IP1794-Ab-1/ GM-Tg-rg-IP1794-Ab-2; GM-Tg-mg-IP1794-Ab-1/ GM-Tg-mg-IP1794-Ab-2; GM-Tg-cynog-IP1794-Ab-1/ GM-Tg-cynog-IP1794-Ab-2; GM-Tg-felg-IP1794-Ab-1/ GM-Tg-felg-IP1794-Ab-2; GM-Tg-cang-IP1794-Ab-1/ GM-Tg-cang-IP1794-Ab-2; GM-Tg-bovg-IP1794-Ab-1/ GM-Tg-bovg-IP1794-Ab-2; GM-Tg-equg-IP1794-Ab-1/ GM-Tg-equg-IP1794-Ab-2 |
| Products Name | Anti-SPAST monoclonal antibody |
| Format | mab |
| Target Name | SPAST |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SPAST monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1794-Ag-1 | Recombinant multi-species SPAST/ ADPSP/ FSP2 protein |
Target information
| Target ID | GM-IP1794 |
| Target Name | SPAST |
| Gene ID | 6683,50850,362700,706264,608582,101088156,521442,100054514 |
| Gene Symbol and Synonyms | ADPSP,FSP2,mKIAA1083,SPAST,SPG4 |
| Uniprot Accession | Q9UBP0,B2RYN7,A2VDN5 |
| Uniprot Entry Name | SPAST_HUMAN,SPAST_RAT,SPAST_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | IgA glomerulonephritis |
| Gene Ensembl | ENSG00000021574 |
| Target Classification | N/A |
The target: SPAST, gene name: SPAST, also named as ADPSP, FSP2, SPG4. This gene encodes a member of the AAA (ATPases associated with a variety of cellular activities) protein family. Members of this protein family share an ATPase domain and have roles in diverse cellular processes including membrane trafficking, intracellular motility, organelle biogenesis, protein folding, and proteolysis. The use of alternative translational initiation sites in this gene results in a single transcript variant that can produce isoforms that differ in the length of their N-terminus and which thereby differ in the efficiency of their export from the nucleus to the cytoplasm. In addition, alternative splicing results in multiple transcript variants that encode isoforms that differ in other protein regions as well. One isoform of this gene has been shown to be a microtubule-severing enzyme that regulates microtubule abundance, mobility, and plus-end distribution. Mutations in this gene cause the most frequent form of autosomal dominant spastic paraplegia 4. [provided by RefSeq, May 2018].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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