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Anti-SPI1 monoclonal antibody
Pre-made anti-SPI1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SPI1/SPI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1810-Ab-1/ GM-Tg-hg-IP1810-Ab-2 | Anti-Human SPI1 monoclonal antibody | Human |
| GM-Tg-rg-IP1810-Ab-1/ GM-Tg-rg-IP1810-Ab-2 | Anti-Rat SPI1 monoclonal antibody | Rat |
| GM-Tg-mg-IP1810-Ab-1/ GM-Tg-mg-IP1810-Ab-2 | Anti-Mouse SPI1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1810-Ab-1/ GM-Tg-cynog-IP1810-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPI1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1810-Ab-1/ GM-Tg-felg-IP1810-Ab-2 | Anti-Feline SPI1 monoclonal antibody | Feline |
| GM-Tg-cang-IP1810-Ab-1/ GM-Tg-cang-IP1810-Ab-2 | Anti-Canine SPI1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1810-Ab-1/ GM-Tg-bovg-IP1810-Ab-2 | Anti-Bovine SPI1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1810-Ab-1/ GM-Tg-equg-IP1810-Ab-2 | Anti-Equine SPI1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1810-Ab-1/ GM-Tg-hg-IP1810-Ab-2; GM-Tg-rg-IP1810-Ab-1/ GM-Tg-rg-IP1810-Ab-2; GM-Tg-mg-IP1810-Ab-1/ GM-Tg-mg-IP1810-Ab-2; GM-Tg-cynog-IP1810-Ab-1/ GM-Tg-cynog-IP1810-Ab-2; GM-Tg-felg-IP1810-Ab-1/ GM-Tg-felg-IP1810-Ab-2; GM-Tg-cang-IP1810-Ab-1/ GM-Tg-cang-IP1810-Ab-2; GM-Tg-bovg-IP1810-Ab-1/ GM-Tg-bovg-IP1810-Ab-2; GM-Tg-equg-IP1810-Ab-1/ GM-Tg-equg-IP1810-Ab-2 |
| Products Name | Anti-SPI1 monoclonal antibody |
| Format | mab |
| Target Name | SPI1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SPI1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1810-Ag-1 | Recombinant multi-species SPI1/ OF/ PU.1 protein |
| ORF Viral Vector | pGMLP003970 | human SPI1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003970 | human SPI1 Lentivirus particle |
| ORF Viral Vector | pGMLPm000571 | mouse Spi1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000571 | mouse Spi1 Lentivirus particle |
Target information
| Target ID | GM-IP1810 |
| Target Name | SPI1 |
| Gene ID | 6688,20375,366126,712010,611255,101094951,507100,100051397 |
| Gene Symbol and Synonyms | AGM10,Dis-1,Dis1,OF,PU.1,Sfpi-1,SFPI1,SPI-1,SPI-A,SPI1,SPI1/PU.1,Tcfpu1,Tfpu.1 |
| Uniprot Accession | P17947,Q6BDS1 |
| Uniprot Entry Name | SPI1_HUMAN,SPI1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000066336 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SPI1, gene name: SPI1, also named as OF, PU.1, SFPI1, SPI-1, SPI-A. This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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