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Anti-SYNE4 monoclonal antibody
Pre-made anti-SYNE4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SYNE4/SYNE4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1866-Ab-1/ GM-Tg-hg-IP1866-Ab-2 | Anti-Human SYNE4 monoclonal antibody | Human |
| GM-Tg-rg-IP1866-Ab-1/ GM-Tg-rg-IP1866-Ab-2 | Anti-Rat SYNE4 monoclonal antibody | Rat |
| GM-Tg-mg-IP1866-Ab-1/ GM-Tg-mg-IP1866-Ab-2 | Anti-Mouse SYNE4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1866-Ab-1/ GM-Tg-cynog-IP1866-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SYNE4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1866-Ab-1/ GM-Tg-felg-IP1866-Ab-2 | Anti-Feline SYNE4 monoclonal antibody | Feline |
| GM-Tg-cang-IP1866-Ab-1/ GM-Tg-cang-IP1866-Ab-2 | Anti-Canine SYNE4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP1866-Ab-1/ GM-Tg-bovg-IP1866-Ab-2 | Anti-Bovine SYNE4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP1866-Ab-1/ GM-Tg-equg-IP1866-Ab-2 | Anti-Equine SYNE4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1866-Ab-1/ GM-Tg-hg-IP1866-Ab-2; GM-Tg-rg-IP1866-Ab-1/ GM-Tg-rg-IP1866-Ab-2; GM-Tg-mg-IP1866-Ab-1/ GM-Tg-mg-IP1866-Ab-2; GM-Tg-cynog-IP1866-Ab-1/ GM-Tg-cynog-IP1866-Ab-2; GM-Tg-felg-IP1866-Ab-1/ GM-Tg-felg-IP1866-Ab-2; GM-Tg-cang-IP1866-Ab-1/ GM-Tg-cang-IP1866-Ab-2; GM-Tg-bovg-IP1866-Ab-1/ GM-Tg-bovg-IP1866-Ab-2; GM-Tg-equg-IP1866-Ab-1/ GM-Tg-equg-IP1866-Ab-2 |
| Products Name | Anti-SYNE4 monoclonal antibody |
| Format | mab |
| Target Name | SYNE4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SYNE4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1866-Ag-1 | Recombinant multi-species SYNE4/ C19orf46/ DFNB76 protein |
Target information
| Target ID | GM-IP1866 |
| Target Name | SYNE4 |
| Gene ID | 163183,233066,292781,711904,612623,101082452,509061,100051801 |
| Gene Symbol and Synonyms | 0610012K07Rik,C18H19orf46,C19H19orf46,C19orf46,C1H19orf46,DFNB76,KASH4,Nesp4,RGD1304580,SYNE4,Syne4l1 |
| Uniprot Accession | Q8N205,Q5M844 |
| Uniprot Entry Name | SYNE4_HUMAN,SYNE4_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000181392 |
| Target Classification | N/A |
The target: SYNE4, gene name: SYNE4, also named as C19orf46, DFNB76, KASH4, Nesp4. This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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