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Anti-TAPBP monoclonal antibody
Pre-made anti-TAPBP monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TAPBP/TAPBP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP1882-Ab-1/ GM-Tg-hg-IP1882-Ab-2 | Anti-Human TAPBP monoclonal antibody | Human |
| GM-Tg-rg-IP1882-Ab-1/ GM-Tg-rg-IP1882-Ab-2 | Anti-Rat TAPBP monoclonal antibody | Rat |
| GM-Tg-mg-IP1882-Ab-1/ GM-Tg-mg-IP1882-Ab-2 | Anti-Mouse TAPBP monoclonal antibody | Mouse |
| GM-Tg-cynog-IP1882-Ab-1/ GM-Tg-cynog-IP1882-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TAPBP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP1882-Ab-1/ GM-Tg-felg-IP1882-Ab-2 | Anti-Feline TAPBP monoclonal antibody | Feline |
| GM-Tg-cang-IP1882-Ab-1/ GM-Tg-cang-IP1882-Ab-2 | Anti-Canine TAPBP monoclonal antibody | Canine |
| GM-Tg-bovg-IP1882-Ab-1/ GM-Tg-bovg-IP1882-Ab-2 | Anti-Bovine TAPBP monoclonal antibody | Bovine |
| GM-Tg-equg-IP1882-Ab-1/ GM-Tg-equg-IP1882-Ab-2 | Anti-Equine TAPBP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP1882-Ab-1/ GM-Tg-hg-IP1882-Ab-2; GM-Tg-rg-IP1882-Ab-1/ GM-Tg-rg-IP1882-Ab-2; GM-Tg-mg-IP1882-Ab-1/ GM-Tg-mg-IP1882-Ab-2; GM-Tg-cynog-IP1882-Ab-1/ GM-Tg-cynog-IP1882-Ab-2; GM-Tg-felg-IP1882-Ab-1/ GM-Tg-felg-IP1882-Ab-2; GM-Tg-cang-IP1882-Ab-1/ GM-Tg-cang-IP1882-Ab-2; GM-Tg-bovg-IP1882-Ab-1/ GM-Tg-bovg-IP1882-Ab-2; GM-Tg-equg-IP1882-Ab-1/ GM-Tg-equg-IP1882-Ab-2 |
| Products Name | Anti-TAPBP monoclonal antibody |
| Format | mab |
| Target Name | TAPBP |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TAPBP monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP1882-Ag-1 | Recombinant multi-species TPSN/ TAPBP/ NGS17 protein |
| ORF Viral Vector | pGMLPm001377 | mouse Tapbp Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001377 | mouse Tapbp Lentivirus particle |
Target information
| Target ID | GM-IP1882 |
| Target Name | TAPBP |
| Gene ID | 6892,21356,25217,718235,481740,101091023,504335,100061515 |
| Gene Symbol and Synonyms | D17Wsu91e,NGS17,TAPA,TAPBP,TPN,TPSN |
| Uniprot Accession | O15533,Q5TJE4 |
| Uniprot Entry Name | TPSN_HUMAN,TPSN_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000231925 |
| Target Classification | N/A |
The target: TAPBP, gene name: TAPBP, also named as NGS17, TAPA, TPN, TPSN. This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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