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Anti-™IE monoclonal antibody
Pre-made anti-™IE monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ™IE/™IE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2142-Ab-1/ GM-Tg-hg-IP2142-Ab-2 | Anti-Human ™IE monoclonal antibody | Human |
| GM-Tg-rg-IP2142-Ab-1/ GM-Tg-rg-IP2142-Ab-2 | Anti-Rat ™IE monoclonal antibody | Rat |
| GM-Tg-mg-IP2142-Ab-1/ GM-Tg-mg-IP2142-Ab-2 | Anti-Mouse ™IE monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2142-Ab-1/ GM-Tg-cynog-IP2142-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™IE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2142-Ab-1/ GM-Tg-felg-IP2142-Ab-2 | Anti-Feline ™IE monoclonal antibody | Feline |
| GM-Tg-cang-IP2142-Ab-1/ GM-Tg-cang-IP2142-Ab-2 | Anti-Canine ™IE monoclonal antibody | Canine |
| GM-Tg-bovg-IP2142-Ab-1/ GM-Tg-bovg-IP2142-Ab-2 | Anti-Bovine ™IE monoclonal antibody | Bovine |
| GM-Tg-equg-IP2142-Ab-1/ GM-Tg-equg-IP2142-Ab-2 | Anti-Equine ™IE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2142-Ab-1/ GM-Tg-hg-IP2142-Ab-2; GM-Tg-rg-IP2142-Ab-1/ GM-Tg-rg-IP2142-Ab-2; GM-Tg-mg-IP2142-Ab-1/ GM-Tg-mg-IP2142-Ab-2; GM-Tg-cynog-IP2142-Ab-1/ GM-Tg-cynog-IP2142-Ab-2; GM-Tg-felg-IP2142-Ab-1/ GM-Tg-felg-IP2142-Ab-2; GM-Tg-cang-IP2142-Ab-1/ GM-Tg-cang-IP2142-Ab-2; GM-Tg-bovg-IP2142-Ab-1/ GM-Tg-bovg-IP2142-Ab-2; GM-Tg-equg-IP2142-Ab-1/ GM-Tg-equg-IP2142-Ab-2 |
| Products Name | Anti-™IE monoclonal antibody |
| Format | mab |
| Target Name | ™IE |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-™IE monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2142-Ag-1 | Recombinant multi-species ™IE/ DFNB6 protein |
Target information
| Target ID | GM-IP2142 |
| Target Name | ™IE |
| Gene ID | 259236,20776,501061,712706,609350,101084267,617572,100065097 |
| Gene Symbol and Synonyms | 5131400L21Rik,DFNB6,Mm.87012,RGD1562523,sr,™IE |
| Uniprot Accession | Q8NEW7 |
| Uniprot Entry Name | ™IE_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000181585 |
| Target Classification | N/A |
The target: ™IE, gene name: ™IE, also named as DFNB6. This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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