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Anti-™PRSS3 monoclonal antibody
Pre-made anti-™PRSS3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ™PRSS3/™PRSS3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2147-Ab-1/ GM-Tg-hg-IP2147-Ab-2 | Anti-Human ™PRSS3 monoclonal antibody | Human |
| GM-Tg-rg-IP2147-Ab-1/ GM-Tg-rg-IP2147-Ab-2 | Anti-Rat ™PRSS3 monoclonal antibody | Rat |
| GM-Tg-mg-IP2147-Ab-1/ GM-Tg-mg-IP2147-Ab-2 | Anti-Mouse ™PRSS3 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2147-Ab-1/ GM-Tg-cynog-IP2147-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ™PRSS3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2147-Ab-1/ GM-Tg-felg-IP2147-Ab-2 | Anti-Feline ™PRSS3 monoclonal antibody | Feline |
| GM-Tg-cang-IP2147-Ab-1/ GM-Tg-cang-IP2147-Ab-2 | Anti-Canine ™PRSS3 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2147-Ab-1/ GM-Tg-bovg-IP2147-Ab-2 | Anti-Bovine ™PRSS3 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2147-Ab-1/ GM-Tg-equg-IP2147-Ab-2 | Anti-Equine ™PRSS3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2147-Ab-1/ GM-Tg-hg-IP2147-Ab-2; GM-Tg-rg-IP2147-Ab-1/ GM-Tg-rg-IP2147-Ab-2; GM-Tg-mg-IP2147-Ab-1/ GM-Tg-mg-IP2147-Ab-2; GM-Tg-cynog-IP2147-Ab-1/ GM-Tg-cynog-IP2147-Ab-2; GM-Tg-felg-IP2147-Ab-1/ GM-Tg-felg-IP2147-Ab-2; GM-Tg-cang-IP2147-Ab-1/ GM-Tg-cang-IP2147-Ab-2; GM-Tg-bovg-IP2147-Ab-1/ GM-Tg-bovg-IP2147-Ab-2; GM-Tg-equg-IP2147-Ab-1/ GM-Tg-equg-IP2147-Ab-2 |
| Products Name | Anti-™PRSS3 monoclonal antibody |
| Format | mab |
| Target Name | ™PRSS3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-™PRSS3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2147-Ag-1 | Recombinant multi-species ™PS3/ ™PRSS3/ DFNB10 protein |
| ORF Viral Vector | vGMLP001748 | human ™PRSS3 Lentivirus particle |
| ORF Viral Vector | pGMLP001748 | human ™PRSS3 Lentivirus plasmid |
Target information
| Target ID | GM-IP2147 |
| Target Name | ™PRSS3 |
| Gene ID | 64699,140765,309665,714500,610987,101094284,537914,100057972 |
| Gene Symbol and Synonyms | DFNB10,DFNB8,ECHOS1,TADG12,™PRSS3 |
| Uniprot Accession | P57727 |
| Uniprot Entry Name | ™PS3_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000160183 |
| Target Classification | N/A |
The target: ™PRSS3, gene name: ™PRSS3, also named as DFNB10, DFNB8, ECHOS1, TADG12. This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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