- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-UGT1A4 monoclonal antibody
Pre-made anti-UGT1A4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to UGT1A4/UGT1A4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2226-Ab-1/ GM-Tg-hg-IP2226-Ab-2 | Anti-Human UGT1A4 monoclonal antibody | Human |
| GM-Tg-rg-IP2226-Ab-1/ GM-Tg-rg-IP2226-Ab-2 | Anti-Rat UGT1A4 monoclonal antibody | Rat |
| GM-Tg-mg-IP2226-Ab-1/ GM-Tg-mg-IP2226-Ab-2 | Anti-Mouse UGT1A4 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2226-Ab-1/ GM-Tg-cynog-IP2226-Ab-2 | Anti-Cynomolgus/ Rhesus macaque UGT1A4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2226-Ab-1/ GM-Tg-felg-IP2226-Ab-2 | Anti-Feline UGT1A4 monoclonal antibody | Feline |
| GM-Tg-cang-IP2226-Ab-1/ GM-Tg-cang-IP2226-Ab-2 | Anti-Canine UGT1A4 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2226-Ab-1/ GM-Tg-bovg-IP2226-Ab-2 | Anti-Bovine UGT1A4 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2226-Ab-1/ GM-Tg-equg-IP2226-Ab-2 | Anti-Equine UGT1A4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2226-Ab-1/ GM-Tg-hg-IP2226-Ab-2; GM-Tg-rg-IP2226-Ab-1/ GM-Tg-rg-IP2226-Ab-2; GM-Tg-mg-IP2226-Ab-1/ GM-Tg-mg-IP2226-Ab-2; GM-Tg-cynog-IP2226-Ab-1/ GM-Tg-cynog-IP2226-Ab-2; GM-Tg-felg-IP2226-Ab-1/ GM-Tg-felg-IP2226-Ab-2; GM-Tg-cang-IP2226-Ab-1/ GM-Tg-cang-IP2226-Ab-2; GM-Tg-bovg-IP2226-Ab-1/ GM-Tg-bovg-IP2226-Ab-2; GM-Tg-equg-IP2226-Ab-1/ GM-Tg-equg-IP2226-Ab-2 |
| Products Name | Anti-UGT1A4 monoclonal antibody |
| Format | mab |
| Target Name | UGT1A4 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-UGT1A4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2226-Ag-1 | Recombinant multi-species UD14/ UGT1A4/ GNT1 protein |
| ORF Viral Vector | vGMLP000796 | human UGT1A4 Lentivirus particle |
| ORF Viral Vector | pGMLP000796 | human UGT1A4 Lentivirus plasmid |
Target information
| Target ID | GM-IP2226 |
| Target Name | UGT1A4 |
| Gene ID | 54657 |
| Gene Symbol and Synonyms | GNT1,hUG-BR1,HUG-BR2,UDPGT,UDPGT 1-4,UGT-1A,UGT-1D,UGT1,UGT1-01,UGT1-04,UGT1.1,UGT1.4,UGT1A,UGT1A1,UGT1A4,UGT1A4S,UGT1D |
| Uniprot Accession | P22310 |
| Uniprot Entry Name | UD14_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000244474 |
| Target Classification | N/A |
The target: UGT1A4, gene name: UGT1A4, also named as GNT1, HUG-BR2, UDPGT, UDPGT 1-4, UGT-1A, UGT-1D, UGT1, UGT1-01, UGT1-04, UGT1.1, UGT1.4, UGT1A, UGT1A1S, UGT1D, hUG-BR1, UGT1A4. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
