Anti-UNC5CL monoclonal antibody

Pre-made anti-UNC5CL monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to UNC5CL/UNC5CL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-IP2245-Ab-1/ GM-Tg-hg-IP2245-Ab-2Anti-Human UNC5CL monoclonal antibodyHuman
GM-Tg-rg-IP2245-Ab-1/ GM-Tg-rg-IP2245-Ab-2Anti-Rat UNC5CL monoclonal antibodyRat
GM-Tg-mg-IP2245-Ab-1/ GM-Tg-mg-IP2245-Ab-2Anti-Mouse UNC5CL monoclonal antibodyMouse
GM-Tg-cynog-IP2245-Ab-1/ GM-Tg-cynog-IP2245-Ab-2Anti-Cynomolgus/ Rhesus macaque UNC5CL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-IP2245-Ab-1/ GM-Tg-felg-IP2245-Ab-2Anti-Feline UNC5CL monoclonal antibodyFeline
GM-Tg-cang-IP2245-Ab-1/ GM-Tg-cang-IP2245-Ab-2Anti-Canine UNC5CL monoclonal antibodyCanine
GM-Tg-bovg-IP2245-Ab-1/ GM-Tg-bovg-IP2245-Ab-2Anti-Bovine UNC5CL monoclonal antibodyBovine
GM-Tg-equg-IP2245-Ab-1/ GM-Tg-equg-IP2245-Ab-2Anti-Equine UNC5CL monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-IP2245-Ab-1/ GM-Tg-hg-IP2245-Ab-2; GM-Tg-rg-IP2245-Ab-1/ GM-Tg-rg-IP2245-Ab-2;
GM-Tg-mg-IP2245-Ab-1/ GM-Tg-mg-IP2245-Ab-2; GM-Tg-cynog-IP2245-Ab-1/ GM-Tg-cynog-IP2245-Ab-2;
GM-Tg-felg-IP2245-Ab-1/ GM-Tg-felg-IP2245-Ab-2; GM-Tg-cang-IP2245-Ab-1/ GM-Tg-cang-IP2245-Ab-2;
GM-Tg-bovg-IP2245-Ab-1/ GM-Tg-bovg-IP2245-Ab-2; GM-Tg-equg-IP2245-Ab-1/ GM-Tg-equg-IP2245-Ab-2
Products NameAnti-UNC5CL monoclonal antibody
Formatmab
Target NameUNC5CL
Protein Sub-locationIntrocelluar Protein
Category of antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-UNC5CL monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-IP2245-Ag-1Recombinant multi-species UN5CL/ UNC5CL/ MUXA protein


    Target information

    Target IDGM-IP2245
    Target NameUNC5CL
    Gene ID222643,76589,301225,719655,481786,101097396,615134,100066002
    Gene Symbol and Synonyms2510009H09Rik,MUXA,UNC5CL,ZUD
    Uniprot AccessionQ8IV45
    Uniprot Entry NameUN5CL_HUMAN
    Protein Sub-locationIntrocelluar Protein
    Category
    DiseaseN/A
    Gene EnsemblENSG00000124602
    Target ClassificationN/A

    The target: UNC5CL, gene name: UNC5CL, also named as MUXA, ZUD. Enables peptidase activity. Acts upstream of or within positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.