- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-VRK1 monoclonal antibody
Pre-made anti-VRK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to VRK1/VRK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2261-Ab-1/ GM-Tg-hg-IP2261-Ab-2 | Anti-Human VRK1 monoclonal antibody | Human |
| GM-Tg-rg-IP2261-Ab-1/ GM-Tg-rg-IP2261-Ab-2 | Anti-Rat VRK1 monoclonal antibody | Rat |
| GM-Tg-mg-IP2261-Ab-1/ GM-Tg-mg-IP2261-Ab-2 | Anti-Mouse VRK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2261-Ab-1/ GM-Tg-cynog-IP2261-Ab-2 | Anti-Cynomolgus/ Rhesus macaque VRK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2261-Ab-1/ GM-Tg-felg-IP2261-Ab-2 | Anti-Feline VRK1 monoclonal antibody | Feline |
| GM-Tg-cang-IP2261-Ab-1/ GM-Tg-cang-IP2261-Ab-2 | Anti-Canine VRK1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2261-Ab-1/ GM-Tg-bovg-IP2261-Ab-2 | Anti-Bovine VRK1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2261-Ab-1/ GM-Tg-equg-IP2261-Ab-2 | Anti-Equine VRK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2261-Ab-1/ GM-Tg-hg-IP2261-Ab-2; GM-Tg-rg-IP2261-Ab-1/ GM-Tg-rg-IP2261-Ab-2; GM-Tg-mg-IP2261-Ab-1/ GM-Tg-mg-IP2261-Ab-2; GM-Tg-cynog-IP2261-Ab-1/ GM-Tg-cynog-IP2261-Ab-2; GM-Tg-felg-IP2261-Ab-1/ GM-Tg-felg-IP2261-Ab-2; GM-Tg-cang-IP2261-Ab-1/ GM-Tg-cang-IP2261-Ab-2; GM-Tg-bovg-IP2261-Ab-1/ GM-Tg-bovg-IP2261-Ab-2; GM-Tg-equg-IP2261-Ab-1/ GM-Tg-equg-IP2261-Ab-2 |
| Products Name | Anti-VRK1 monoclonal antibody |
| Format | mab |
| Target Name | VRK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-VRK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2261-Ag-1 | Recombinant multi-species VRK1/ PCH1/ PCH1A protein |
| ORF Viral Vector | pGMLPm002109 | mouse Vrk1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002109 | mouse Vrk1 Lentivirus particle |
Target information
| Target ID | GM-IP2261 |
| Target Name | VRK1 |
| Gene ID | 7443,22367,362779,704798,490848,101091879,618880,100050033 |
| Gene Symbol and Synonyms | 51PK,PCH1,PCH1A,VRK1 |
| Uniprot Accession | Q99986,Q32PI1 |
| Uniprot Entry Name | VRK1_HUMAN,VRK1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000100749 |
| Target Classification | N/A |
The target: VRK1, gene name: VRK1, also named as PCH1, PCH1A. This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
