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Anti-WFS1 monoclonal antibody
Pre-made anti-WFS1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to WFS1/WFS1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2280-Ab-1/ GM-Tg-hg-IP2280-Ab-2 | Anti-Human WFS1 monoclonal antibody | Human |
| GM-Tg-rg-IP2280-Ab-1/ GM-Tg-rg-IP2280-Ab-2 | Anti-Rat WFS1 monoclonal antibody | Rat |
| GM-Tg-mg-IP2280-Ab-1/ GM-Tg-mg-IP2280-Ab-2 | Anti-Mouse WFS1 monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2280-Ab-1/ GM-Tg-cynog-IP2280-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WFS1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2280-Ab-1/ GM-Tg-felg-IP2280-Ab-2 | Anti-Feline WFS1 monoclonal antibody | Feline |
| GM-Tg-cang-IP2280-Ab-1/ GM-Tg-cang-IP2280-Ab-2 | Anti-Canine WFS1 monoclonal antibody | Canine |
| GM-Tg-bovg-IP2280-Ab-1/ GM-Tg-bovg-IP2280-Ab-2 | Anti-Bovine WFS1 monoclonal antibody | Bovine |
| GM-Tg-equg-IP2280-Ab-1/ GM-Tg-equg-IP2280-Ab-2 | Anti-Equine WFS1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2280-Ab-1/ GM-Tg-hg-IP2280-Ab-2; GM-Tg-rg-IP2280-Ab-1/ GM-Tg-rg-IP2280-Ab-2; GM-Tg-mg-IP2280-Ab-1/ GM-Tg-mg-IP2280-Ab-2; GM-Tg-cynog-IP2280-Ab-1/ GM-Tg-cynog-IP2280-Ab-2; GM-Tg-felg-IP2280-Ab-1/ GM-Tg-felg-IP2280-Ab-2; GM-Tg-cang-IP2280-Ab-1/ GM-Tg-cang-IP2280-Ab-2; GM-Tg-bovg-IP2280-Ab-1/ GM-Tg-bovg-IP2280-Ab-2; GM-Tg-equg-IP2280-Ab-1/ GM-Tg-equg-IP2280-Ab-2 |
| Products Name | Anti-WFS1 monoclonal antibody |
| Format | mab |
| Target Name | WFS1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-WFS1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2280-Ag-1 | Recombinant multi-species WFS1/ CTRCT41/ WFRS protein |
Target information
| Target ID | GM-IP2280 |
| Target Name | WFS1 |
| Gene ID | 7466,22393,83725,710948,482113,101092024,100298456,100070117 |
| Gene Symbol and Synonyms | CTRCT41,WFRS,WFS,WFS1,WFSL,wolframin |
| Uniprot Accession | O76024 |
| Uniprot Entry Name | WFS1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000109501 |
| Target Classification | N/A |
The target: WFS1, gene name: WFS1, also named as CTRCT41, WFRS, WFS, WFSL. This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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