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Anti-YWHAQ monoclonal antibody
Pre-made anti-YWHAQ monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to YWHAQ/YWHAQ products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-IP2293-Ab-1/ GM-Tg-hg-IP2293-Ab-2 | Anti-Human YWHAQ monoclonal antibody | Human |
| GM-Tg-rg-IP2293-Ab-1/ GM-Tg-rg-IP2293-Ab-2 | Anti-Rat YWHAQ monoclonal antibody | Rat |
| GM-Tg-mg-IP2293-Ab-1/ GM-Tg-mg-IP2293-Ab-2 | Anti-Mouse YWHAQ monoclonal antibody | Mouse |
| GM-Tg-cynog-IP2293-Ab-1/ GM-Tg-cynog-IP2293-Ab-2 | Anti-Cynomolgus/ Rhesus macaque YWHAQ monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-IP2293-Ab-1/ GM-Tg-felg-IP2293-Ab-2 | Anti-Feline YWHAQ monoclonal antibody | Feline |
| GM-Tg-cang-IP2293-Ab-1/ GM-Tg-cang-IP2293-Ab-2 | Anti-Canine YWHAQ monoclonal antibody | Canine |
| GM-Tg-bovg-IP2293-Ab-1/ GM-Tg-bovg-IP2293-Ab-2 | Anti-Bovine YWHAQ monoclonal antibody | Bovine |
| GM-Tg-equg-IP2293-Ab-1/ GM-Tg-equg-IP2293-Ab-2 | Anti-Equine YWHAQ monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-IP2293-Ab-1/ GM-Tg-hg-IP2293-Ab-2; GM-Tg-rg-IP2293-Ab-1/ GM-Tg-rg-IP2293-Ab-2; GM-Tg-mg-IP2293-Ab-1/ GM-Tg-mg-IP2293-Ab-2; GM-Tg-cynog-IP2293-Ab-1/ GM-Tg-cynog-IP2293-Ab-2; GM-Tg-felg-IP2293-Ab-1/ GM-Tg-felg-IP2293-Ab-2; GM-Tg-cang-IP2293-Ab-1/ GM-Tg-cang-IP2293-Ab-2; GM-Tg-bovg-IP2293-Ab-1/ GM-Tg-bovg-IP2293-Ab-2; GM-Tg-equg-IP2293-Ab-1/ GM-Tg-equg-IP2293-Ab-2 |
| Products Name | Anti-YWHAQ monoclonal antibody |
| Format | mab |
| Target Name | YWHAQ |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-YWHAQ monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-IP2293-Ag-1 | Recombinant multi-species 1433T/ YWHAQ/ 2014-3-3 protein |
| ORF Viral Vector | vGMAP000259 | Human YWHAQ Adenovirus particle |
| ORF Viral Vector | vGMLP000536 | human YWHAQ Lentivirus particle |
| ORF Viral Vector | pGMLP000536 | human YWHAQ Lentivirus plasmid |
| ORF Viral Vector | pGMAP000259 | Human YWHAQ Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000471 | mouse Ywhaq Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000471 | mouse Ywhaq Lentivirus particle |
Target information
| Target ID | GM-IP2293 |
| Target Name | YWHAQ |
| Gene ID | 10971,22630,25577,694702,607060,101088481,768311,100057123 |
| Gene Symbol and Synonyms | 14-3-3,14-3-3t,1C5,2700028P07Rik,HS1,YWHAQ |
| Uniprot Accession | P27348,P68255,Q3SZI4 |
| Uniprot Entry Name | 1433T_HUMAN,1433T_RAT,1433T_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000134308 |
| Target Classification | N/A |
The target: YWHAQ, gene name: YWHAQ, also named as 14-3-3, 1C5, HS1. This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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